Chen-Yuan Lee
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Chen-Yuan Lee (; December 4, 1915 – November 1, 2001), was a
Taiwanese Taiwanese may refer to: * Taiwanese language, another name for Taiwanese Hokkien * Something from or related to Taiwan ( Formosa) * Taiwanese aborigines, the indigenous people of Taiwan * Han Taiwanese, the Han people of Taiwan * Taiwanese people, ...
pharmacologist Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...
and political activist. He is famous for his research on
snake venom Snake venom is a highly toxic saliva containing zootoxins that facilitates in the immobilization and digestion of prey. This also provides defense against threats. Snake venom is injected by unique fangs during a bite, whereas some species are a ...
. He was a recipient of the prestigious Redi Award from the
International Society on Toxinology International Society on Toxinology (IST) is a global society of scientists and clinicians working for the advancement of venoms, poisons and toxins. It was founded in 1962 with an aim to advance knowledge on venoms, poisons and toxins of animal, pl ...
(IST), and was also a former president of the society. He was a former
dean Dean may refer to: People * Dean (given name) * Dean (surname), a surname of Anglo-Saxon English origin * Dean (South Korean singer), a stage name for singer Kwon Hyuk * Dean Delannoit, a Belgian singer most known by the mononym Dean Titles * ...
of the
National Taiwan University National Taiwan University (NTU; ) is a public research university in Taipei, Taiwan. The university was founded in 1928 during Japanese rule as the seventh of the Imperial Universities. It was named Taihoku Imperial University and served d ...
College of Medicine. After his retirement from researching, he focused on participating in the
Taiwan independence movement The Taiwan independence movement is a political movement which advocates the formal declaration of an independent and sovereign Taiwanese state, as opposed to Chinese unification or the status quo in Cross-Strait relations. Currently, Tai ...
and many
democratic movement A democracy is a political system, or a system of decision-making within an institution or organization or a country, in which all members have an equal share of power. Modern democracies are characterized by two capabilities that differentiate ...
. Lee had founded many political organizations such as the "100 Action Union" (100行動聯盟),
Foundation of Medical Professionals Alliance in Taiwan The Foundation of Medical Professionals Alliance in Taiwan (FMPAT; ) is a non-governmental organization based in Taiwan. History Dr Chen-Yuan Lee, a Taiwanese pharmacologist, professor emeritus of the College of Medicine of the National Taiwan U ...
. He was also the first chairperson of the
Taiwan Independence Party The Taiwan Independence Party (TAIP; ), also known as the Taiwan Nation Party, was a political party in Taiwan. It was usually associated with the Pan-Green Coalition and supported Taiwan independence. History Disappointed by the Democratic P ...
.


Early years

Lee was born in
Takao Prefecture was one of the administrative divisions of Taiwan during the Japanese rule. The prefecture consisted of modern-day Kaohsiung City and Pingtung County. Population Administrative divisions Cities and districts In 1945 ( Shōwa 20), the ...
(present-day
Kaohsiung Kaohsiung City (Mandarin Chinese: ; Wade–Giles: ''Kao¹-hsiung²;'' Pinyin: ''Gāoxióng'') is a special municipality located in southern Taiwan. It ranges from the coastal urban center to the rural Yushan Range with an area of . Kaohsi ...
),
Taiwan Taiwan, officially the Republic of China (ROC), is a country in East Asia, at the junction of the East and South China Seas in the northwestern Pacific Ocean, with the People's Republic of China (PRC) to the northwest, Japan to the nort ...
in 1915. Both of his parents were from
Tainan Tainan (), officially Tainan City, is a Special municipality (Taiwan), special municipality in southern Taiwan facing the Taiwan Strait on its western coast. Tainan is the oldest city on the island and also commonly known as the "Capital City" ...
. Lee chose to become a
medical doctor A physician (American English), medical practitioner (Commonwealth English), medical doctor, or simply doctor, is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through th ...
after his father and three of his siblings died of
malaria Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. S ...
and
infectious disease An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable dise ...
s. Lee grew up in Tainan, where he had outstanding grades. After graduating from the Tainan Prefecture Second High School (now the
National Tainan First Senior High School The National Tainan First Senior High School () is a public senior high school in East District, Tainan, Taiwan. It was established in 1922 and is considered one of the most prestigious high schools in Taiwan, usually only accepting students who ...
), he attended the Taihoku School of Higher Education (臺北高等學校). He entered the medical department of
Taihoku Imperial University National Taiwan University (NTU; ) is a public research university in Taipei, Taiwan. The university was founded in 1928 during Taiwan under Japanese rule, Japanese rule as the seventh of the Imperial Universities. It was named Taihoku Imper ...
in 1936, and became one of the first graduates from the department. Lee enjoyed basic medical studies after entering the medical department. He finished his first research paper in his freshman year, which was published in the ''Taiwanese Medical Magazine'' (台灣醫學雜誌). After graduating in 1940, Lee decided to quit
clinical medicine Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practice ...
and keep on studying. He became the assistant of
Tu Tsung-ming Tu Tsung-ming (, ja, Tō Sōmē), was the first Doctor of Medical Sciences (equivalent to Ph.D.) of Taiwan. He was born in Tamsui in 1893, trained as a physician at Taiwan Governor's Medical School, and received his doctorate degree from Kyoto Im ...
, who was researching on basic medical studies and, at the time, the only Taiwanese professors in the medical department. He once said, ''To gain honor for Taiwan, dignity for the Taiwanese, I chose to follow Professor Tu instead of several other Japanese professors. Because I thought Professor Tu was our people, and we should help him.''


Career and achievements

The first research Lee did after becoming Tu's assistant was the "Using ''Kushenji'' (苦蔘子) to cure
dysentery Dysentery (UK pronunciation: , US: ), historically known as the bloody flux, is a type of gastroenteritis that results in bloody diarrhea. Other symptoms may include fever, abdominal pain, and a feeling of incomplete defecation. Complications ...
." He discovered that the
glycoside In chemistry, a glycoside is a molecule in which a sugar is bound to another functional group via a glycosidic bond. Glycosides play numerous important roles in living organisms. Many plants store chemicals in the form of inactive glycosides. ...
s contained in the ''Kushenji'' can be used to kill an
amoeba An amoeba (; less commonly spelled ameba or amœba; plural ''am(o)ebas'' or ''am(o)ebae'' ), often called an amoeboid, is a type of Cell (biology), cell or unicellular organism with the ability to alter its shape, primarily by extending and ret ...
, and solved a Chinese herbological myth on how the ''Kushenji'' cures dysentery. In 1945, Lee published a research paper with a title of "The Toxicological Research on the Venom of
Daboia ''Daboia'' is a genus of venomous vipers.. Species The following four species are recognized as being valid: *''Daboia mauritanica'' – Moorish viper *''Daboia palaestinae'' – Palestine viper *''Daboia russelii'' – Russell's viper *''Da ...
" (鎖鏈蛇蛇毒的毒物學研究), the paper was world's first paper to explain the cause of death by the venom of
Daboia ''Daboia'' is a genus of venomous vipers.. Species The following four species are recognized as being valid: *''Daboia mauritanica'' – Moorish viper *''Daboia palaestinae'' – Palestine viper *''Daboia russelii'' – Russell's viper *''Da ...
. Because of this outstanding achievement, Lee was recognized by getting his
medical doctor A physician (American English), medical practitioner (Commonwealth English), medical doctor, or simply doctor, is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through th ...
degree. This recognition began his career as researching snake venom. In 1952, Lee was financially supported by the Economic Cooperation Administration (美援會) and was sent to the
University of Pennsylvania Medical School The Perelman School of Medicine, commonly known as Penn Med, is the medical school of the University of Pennsylvania, a private research university in Philadelphia, Pennsylvania. Founded in 1765, the Perelman School of Medicine is the oldest medi ...
for further education. This was his first time
studying abroad International students, or foreign students, are students who undertake all or part of their tertiary education in a country other than their own and move to that country for the purpose of studying. In 2019, there were over 6 million internati ...
. Lee originally wanted to do research on the
circulatory system The blood circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the entire body of a human or other vertebrate. It includes the cardiovascular system, or vascular system, tha ...
, but because of the limitation of time, his instructor Carl F. Schmidt suggested that he change his topic to
pulmonary circulation The pulmonary circulation is a division of the circulatory system in all vertebrates. The circuit begins with deoxygenated blood returned from the body to the right atrium of the heart where it is pumped out from the right ventricle to the lungs. ...
. After researching at the
University of Pennsylvania The University of Pennsylvania (also known as Penn or UPenn) is a private research university in Philadelphia. It is the fourth-oldest institution of higher education in the United States and is ranked among the highest-regarded universitie ...
, he transferred to
Wayne State University Wayne State University (WSU) is a public research university in Detroit, Michigan. It is Michigan's third-largest university. Founded in 1868, Wayne State consists of 13 schools and colleges offering approximately 350 programs to nearly 25,000 ...
in Detroit, where he visited Walter Segeers's lab for two months and published a small-sized research paper. After Lee's return to
Taiwan Taiwan, officially the Republic of China (ROC), is a country in East Asia, at the junction of the East and South China Seas in the northwestern Pacific Ocean, with the People's Republic of China (PRC) to the northwest, Japan to the nort ...
, he started his job as a leader at the pharmacology lab of
National Taiwan University National Taiwan University (NTU; ) is a public research university in Taipei, Taiwan. The university was founded in 1928 during Japanese rule as the seventh of the Imperial Universities. It was named Taihoku Imperial University and served d ...
due to the dimission of Tsungming Tu. In 1963, Lee worked with Chang Chuan-chung (張傳炯), a
chemist A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties. Chemists carefully describe th ...
, and separated the deadly α-type and β-type
bungarotoxin Bungarotoxins are toxins found in the venom of snakes and kraits. Bites from these animals can result in severe symptoms including bleeding or hemorrhage, paralysis and tissue damage that can result in amputation. The paralytic effects of venom are ...
s of the venom of
Bungarus multicinctus The many-banded krait (''Bungarus multicinctus''), also known as the Taiwanese krait or the Chinese krait, is a venomous species of elapid snake found in much of central and southern China and Southeast Asia. The species was first described by t ...
. This was a big step in
neuroscience Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, development ...
,
medical science Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practice ...
, and
pharmacology Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...
. Over the years, Lee had published over a hundred research papers. He not only became a leader of pharmacology in Taiwan, but also an international authority in the field of venom snake research. In 1970, he was elected a member of
Academia Sinica Academia Sinica (AS, la, 1=Academia Sinica, 3=Chinese Academy; ), headquartered in Nangang, Taipei, is the national academy of Taiwan. Founded in Nanking, the academy supports research activities in a wide variety of disciplines, ranging from ...
, the national academy of Taiwan. He was the second person employed by National Taiwan University's College of Medicine to be elected to Academia Sinica. He became the dean of the National Taiwan University College of Medicine in 1972. Four years later, he was awarded the "Redi Prize" by the International Society on Toxinology. In 1979, he received an invitation from
Springer Science+Business Media Springer Science+Business Media, commonly known as Springer, is a German multinational publishing company of books, e-books and peer-reviewed journals in science, humanities, technical and medical (STM) publishing. Originally founded in 1842 in ...
to serve as the chief editor for the books ''Chemistry of Protein Toxins in Snake Venoms'' and ''The Action of Snake Venoms on Nerve and Muscle'', which established his high position in researching snake venom. In 1985, he chosen to serve as the president of the International Society on Toxinology, and became one of the few Taiwanese scholars to lead an international research organization.
Nobel Prize laureate The Nobel Prizes ( sv, Nobelpriset, no, Nobelprisen) are awarded annually by the Royal Swedish Academy of Sciences, the Swedish Academy, the Karolinska Institutet, and the Norwegian Nobel Committee to individuals and organizations who make out ...
Yuan T. Lee Yuan Tseh Lee (; born 19 November 1936) is a Taiwanese chemist and a Professor Emeritus at the University of California, Berkeley. He was the first Taiwanese Nobel Prize laureate who, along with the Hungarian-Canadian John C. Polanyi and America ...
wrote in the foreword of the book ''The Story of Snake Venom Research in Taiwan'' (台灣蛇毒傳奇) that he once had ask another Nobel Prize laureate
Joseph L. Goldstein Joseph Leonard Goldstein ForMemRS (born April 18, 1940) is an American biochemist. He received the Nobel Prize in Physiology or Medicine in 1985, along with fellow University of Texas Southwestern researcher, Michael Brown, for their studies re ...
, "In the Taiwanese life science field, whose research is recognized internationally?" Without the least hesitation, Goldstein answered, "Chen-Yuan Lee is internationally recognized."大紀元 2001 Lee retired in 1986 from
National Taiwan University National Taiwan University (NTU; ) is a public research university in Taipei, Taiwan. The university was founded in 1928 during Japanese rule as the seventh of the Imperial Universities. It was named Taihoku Imperial University and served d ...
College of Medicine, and was immediately named a
professor emeritus ''Emeritus'' (; female: ''emerita'') is an adjective used to designate a retired chair, professor, pastor, bishop, pope, director, president, prime minister, rabbi, emperor, or other person who has been "permitted to retain as an honorary title ...
by the university.


Entry into politics

In March 1990, over 300,000 students participated in the
Wild Lily student movement Taiwan's Wild Lily student movement () or March student movement was a six-day student demonstration in 1990 for democracy. The sit-in at Memorial Square in Taipei (since rededicated as Liberty Square in commemoration of the movement) was ini ...
for
democratic reform Democratization, or democratisation, is the transition to a more democratic political regime, including substantive political changes moving in a democratic direction. It may be a hybrid regime in transition from an authoritarian regime to a full ...
. Lee, who was almost eighty years old, accompanied the protesting students. This was his first time participating in a
political movement A political movement is a collective attempt by a group of people to change government policy or social values. Political movements are usually in opposition to an element of the status quo, and are often associated with a certain ideology. Some t ...
. In 1991, along with several colleagues, Chen-Yuan Lee visited Ying-Yuan Lee and Kuo Pei-hung (郭倍宏), two
Taiwan Independence Taiwan, officially the Republic of China (ROC), is a country in East Asia, at the junction of the East and South China Seas in the northwestern Pacific Ocean, with the People's Republic of China (PRC) to the northwest, Japan to the northeast ...
supporters and alumni of the
National Taiwan University National Taiwan University (NTU; ) is a public research university in Taipei, Taiwan. The university was founded in 1928 during Japanese rule as the seventh of the Imperial Universities. It was named Taihoku Imperial University and served d ...
who were arrested for "planning to revolt" (預備叛亂罪) and were detained in the Tucheng Detention Center (土城看守所). Later, he felt that the "Regulation for Rebellions" (懲治叛亂條例) and "Criminal Law Article 100" (刑法第100條) impeded the democratic development of Taiwan because they were simply tools to help
Kuomintang The Kuomintang (KMT), also referred to as the Guomindang (GMD), the Nationalist Party of China (NPC) or the Chinese Nationalist Party (CNP), is a major political party in the Republic of China, initially on the Chinese mainland and in Tai ...
dominate Taiwan. As a result, he organized the "100 Action Union," which stands for the abolishment of "Criminal Law Article 100." He, as a member of
Academia Sinica Academia Sinica (AS, la, 1=Academia Sinica, 3=Chinese Academy; ), headquartered in Nangang, Taipei, is the national academy of Taiwan. Founded in Nanking, the academy supports research activities in a wide variety of disciplines, ranging from ...
, joined a sit-down demonstration, leading the "100 Action Union" and successfully expressed the Taiwanese people's desire for human rights.


References

*符文美,nd, a,蛇毒研究,見李鎮源教授:一位堅持理念之學者 從醫學研究到社會改革 nline台北:教育部健康醫學學習網。 用於2004年12月31日全球資訊網網址

*符文美,nd, b,民主運動與社會改革,見李鎮源教授:一位堅持理念之學者 從醫學研究到社會改革 nline台北:教育部健康醫學學習網。 用於2004年12月31日全球資訊網網址

*符文美,nd, c,重要經歷及學術榮譽,見李鎮源教授:一位堅持理念之學者 從醫學研究到社會改革 nline台北:教育部健康醫學學習網。 用於 2004年12月31日全球資訊網網址

*李瓊月,1995,台灣醫界大師:李鎮源。台北:玉山社。 *Lee, Chen-yuan. eds. 1979. ''Handbook of Experimental Pharmacology: Snake Venoms''. Berlin: Springer-Verlag. *楊美珍,2001,中研院士李鎮源 獲頒賴和特別獎 nline台北:自由新聞網。5月28日 用於2004年12月31日全球資訊網網址

*楊玉齡、羅時成,1996,蛇毒權威李鎮源院士 nline台北:天下遠見出版股份有限公司:科學文化頻道。 用於2004年12月31日全球資訊網網址

*自由時報,2001,一生奉獻台灣 中研院院士李鎮源病逝 nlineWashington, D.C.:Formosan Association for Public Affairs。11月2日 用於2004年11月17日全球資訊網網址


Notes

{{DEFAULTSORT:Lee, Chen-Yuan 1915 births 2001 deaths National Taiwan University alumni Senior Advisors to President Chen Shui-bian Taiwan independence activists Taiwanese pharmacologists Wayne State University faculty Politicians of the Republic of China on Taiwan from Kaohsiung Members of Academia Sinica Taiwan Independence Party chairpersons Taiwanese university and college faculty deans