Charles A. Dinarello (born April 22, 1943) is a professor of medicine at the

University of Colorado at Denver The University of Colorado Denver (CU Denver) is a public research university in Denver, Colorado. It is part of the University of Colorado system. History University of Colorado System Anschutz Medical Campus The University of Colorado create ...

. He is an expert on inflammatory

cytokines Cytokines are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Cytokines are peptides and cannot cross the lipid bilayer of cells to enter the cytoplasm. Cytokines have been shown to be involved in autocrin ...

, specifically

Interleukin 1 The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults. Discovery Discovery of these cytokines began with studies on t ...

Education and career

Dinarello received his

Doctor of Medicine Doctor of Medicine (abbreviated M.D., from the Latin language, Latin ''Medicinae Doctor'') is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the M.D. denotes a profes ...

in 1969 at

Yale University Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the wo ...

and since 1996, he is Professor of Medicine at

University of Colorado School of Medicine The University of Colorado School of Medicine is the medical school of the University of Colorado system. It is located at the Anschutz Medical Campus in Aurora, Colorado, one of the four University of Colorado campuses, six miles east of downtown ...

. He is also Professor of Experimental Medicine at the Radboud University Medical Center in Nijmegen, The Netherlands. Dinarello is considered one of the founding fathers of

having purified and cloned

interleukin-1 The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults. Discovery Discovery of these cytokines began with studies on t ...

. This important step established the validation of cytokines as mediators of disease, particularly of

inflammation Inflammation (from la, wikt:en:inflammatio#Latin, inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or Irritation, irritants, and is a protective response involving im ...

. Current studies blocking IL-1 in humans supports Dinarello's and his co-workers pivotal contributions to cytokine biology and the pathogenesis of inflammatory diseases. He is fluent in English, Italian and German.

Awards

* 1993:

Ernst Jung Prize The Ernst Jung Prize is a prize awarded annually for excellence in biomedical sciences. The Ernst Jung Foundation, funded by Hamburg merchant Ernst Jung in 1967, has awarded the Ernst Jung Prize in Medicine, now €300,000, since 1976, and the lif ...

* 2006: Hamdan Award for Medical Research Excellence, awarded by Sheikh Hamdan bin Rashid Al Maktoum Award for Medical Sciences,

Dubai Dubai (, ; ar, دبي, translit=Dubayy, , ) is the most populous city in the United Arab Emirates (UAE) and the capital of the Emirate of Dubai, the most populated of the 7 emirates of the United Arab Emirates.The Government and Politics of ...

United Arab Emirates The United Arab Emirates (UAE; ar, اَلْإِمَارَات الْعَرَبِيَة الْمُتَحِدَة ), or simply the Emirates ( ar, الِْإمَارَات ), is a country in Western Asia (The Middle East). It is located at th ...

* 2009:

Crafoord Prize The Crafoord Prize is an annual science prize established in 1980 by Holger Crafoord, a Swedish industrialist, and his wife Anna-Greta Crafoord. The Prize is awarded in partnership between the Royal Swedish Academy of Sciences and the Crafoord Foun ...

in Polyarthritis (together with

Tadamitsu Kishimoto is a Japanese immunologist known for research on IgM and cytokines, most famously, interleukin 6. He did postdoctoral work under Kimishige Ishizaka, the discoverer of IgE at Johns Hopkins University. He is listed by the Institute for Scientif ...

and Toshio Hirano) “for their pioneering work to isolate interleukins, determine their properties and explore their role in the onset of inflammatory diseases”. * 2009:

Albany Medical Center Prize The Albany Medical Center Prize in Medicine and Biomedical Research is the United States' second highest value prize in medicine and biomedical research, awarded by the Albany Medical Center. Among prizes for medicine worldwide, the Albany Medical ...

(shared with

Ralph M. Steinman Ralph Marvin Steinman (January 14, 1943 – September 30, 2011) was a Canadian physician and medical researcher at Rockefeller University, who in 1973 discovered and named dendritic cells while working as a postdoctoral fellow in the labora ...

and

Bruce A. Beutler Bruce Alan Beutler ( ; born December 29, 1957) is an American immunologist and geneticist. Together with Jules A. Hoffmann, he received one-half of the 2011 Nobel Prize in Physiology or Medicine, for "their discoveries concerning the activation ...

) * 2010:

Paul Ehrlich and Ludwig Darmstaedter Prize The Paul Ehrlich and Ludwig Darmstaedter Prize is an annual award bestowed by the since 1952 for investigations in medicine. It carries a prize money of 120,000 Euro. The prize awarding ceremony is traditionally held on March 14, the birthday of N ...

* 2010: Novartis Prize in Clinical Immunology (together with Juerg Tschopp). * 2011: Foreign membership of the

Royal Netherlands Academy of Arts and Sciences The Royal Netherlands Academy of Arts and Sciences ( nl, Koninklijke Nederlandse Akademie van Wetenschappen, abbreviated: KNAW) is an organization dedicated to the advancement of science and literature in the Netherlands. The academy is housed ...

* 2020:

Tang Prize The Tang Prize () is a set of biannual international awards bestowed in four fields: Sustainable Development, Biopharmaceutical Science, Sinology, and Rule of Law. Nomination and selection are conducted by an independent selection committee, whic ...

in Biopharmaceutical Science.Tang Prize 2020
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References

External links

Institutional WebsiteInformation about his research from the Royal Swedish Academy of Sciences

NAS
-> 1943 births Living people American immunologists Members of the Royal Netherlands Academy of Arts and Sciences Members of the United States National Academy of Sciences University of Colorado Denver faculty University of Denver faculty {{US-physician-stub