Cefapirin (

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, also spelled cephapirin) is an injectable, first-generation cephalosporin antibiotic. It is marketed under the trade name Cefadyl. Production for use in humans has been discontinued in the United States. It also has a role in

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as Metricure, an intrauterine preparation, and combined with

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in Mastiplan, an intramammary preparation. Both are licensed in

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Synthesis

In one of the syntheses,

7-aminocephalosporanic acid 7-ACA (7-aminocephalosporanic acid) is the core chemical structure (a synthon) for the synthesis of cephalosporin antibiotics and intermediates. It can be obtained by chemoenzymatic hydrolysis of cephalosporin C. See also * 6-APA 6-APA ((+)- ...

(

7-ACA 7-ACA (7-aminocephalosporanic acid) is the core chemical structure (a synthon) for the synthesis of cephalosporin antibiotics and intermediates. It can be obtained by chemoenzymatic hydrolysis of cephalosporin C. See also * 6-APA 6-APA ((+)- ...

) is reacted with bromoacetyl chloride to give the amide. The halo group is then displaced by 4-thiopyridine.

References

Cephalosporin antibiotics Enantiopure drugs 4-Pyridyl compounds Acetate esters {{antibiotic-stub