Centrilobular necrosis refers to the
necrosis
Necrosis () is a form of cell injury which results in the premature death of cells in living tissue by autolysis. Necrosis is caused by factors external to the cell or tissue, such as infection, or trauma which result in the unregulated dige ...
of the centrilobular tissue of the
hepatic lobule.
The centrilobular zone of the lobule is most prone to metabolic toxins such as those generated in
alcoholic hepatitis. In
acetaminophen overdose
Paracetamol poisoning, also known as acetaminophen poisoning, is caused by excessive use of the medication paracetamol (acetaminophen). Most people have few or non-specific symptoms in the first 24 hours following overdose. These include ...
,
glutathione depletion occurs and the highly reactive
NAPQI will bind to the liver cells causing centrilobular necrosis.
References
Necrosis
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