Adverse effects
The chemical structure of cefmetazole, like that of several other cephalosporins, contains an ''N''-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram, due to inhibition of aldehyde dehydrogenase.Spectrum of bacterial susceptibility
Cefmetazole is a broad-spectrum cephalosporin antimicrobial and has been effective in treating bacteria responsible for causing urinary tract and skin infections. The following represents MIC susceptibility data for a few medically significant microorganisms. * ''Bacteroides fragilis'': 0.06 - >256 µg/ml * ''Clostridium difficile'': 8 - >128 µg/ml * ''Staphylococcus aureus'': 0.5 - 256 µg/ml (includes MRSA)References
Acetaldehyde dehydrogenase inhibitors Cephalosporin antibiotics Tetrazoles Nitriles Carboxamides {{antibiotic-stub