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Carl Schotten (12 July 1853 – 9 January 1910) was a German chemist who, together with
Eugen Baumann Eugen Baumann (12 December 1846 – 3 November 1896) was a German chemist. He was one of the first people to create polyvinyl chloride (PVC), and, together with Carl Schotten, he discovered the Schotten-Baumann reaction. Life Baumann was born i ...
, discovered the Schotten-Baumann reaction. The Schotten-Baumann reaction is a method to synthesize
amide In organic chemistry, an amide, also known as an organic amide or a carboxamide, is a compound with the general formula , where R, R', and R″ represent organic groups or hydrogen atoms. The amide group is called a peptide bond when it i ...
s from
amine In chemistry, amines (, ) are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (), wherein one or more hydrogen Hydrogen is the chemical element wi ...
s and
acid chloride In organic chemistry, an acyl chloride (or acid chloride) is an organic compound with the functional group . Their formula is usually written , where R is a side chain. They are reactive derivatives of carboxylic acids (). A specific example o ...
s. Examples of this reaction include the synthesis of N-vanillyl nonanamide, also known as synthetic
capsaicin Capsaicin (8-methyl-''N''-vanillyl-6-nonenamide) ( or ) is an active component of chili peppers, which are plants belonging to the genus ''Capsicum''. It is a chemical irritant for mammals, including humans, and produces a sensation of burnin ...
.


Life and work

Schotten was born as the third child of a syndic at the
University of Marburg The Philipps University of Marburg (german: Philipps-Universität Marburg) was founded in 1527 by Philip I, Landgrave of Hesse, which makes it one of Germany's oldest universities and the oldest still operating Protestant university in the wor ...
, his mother was a daughter of a law professor. Although he lost his father at the age of two, his intellectual family background allowed him to receive a good education. After attending the gymnasium in
Marburg Marburg ( or ) is a university town in the German federal state (''Bundesland'') of Hesse, capital of the Marburg-Biedenkopf district (''Landkreis''). The town area spreads along the valley of the river Lahn and has a population of approxima ...
and
Schulpforta Pforta, or Schulpforta, is a school located in Pforta monastery, a former Cistercian monastery (1137–1540), near Naumburg on the Saale River in the German state of Saxony-Anhalt. The site has been a school since the 16th century. Notable past ...
, he studied medicine at the
University of Zurich The University of Zürich (UZH, german: Universität Zürich) is a public research university located in the city of Zürich, Switzerland. It is the largest university in Switzerland, with its 28,000 enrolled students. It was founded in 1833 f ...
. He later moved to the
University of Leipzig Leipzig University (german: Universität Leipzig), in Leipzig in Saxony, Germany, is one of the world's oldest universities and the second-oldest university (by consecutive years of existence) in Germany. The university was founded on 2 Decemb ...
and changed his subject to chemistry. Schotten joined the group of
August Wilhelm von Hofmann August Wilhelm von Hofmann (8 April 18185 May 1892) was a German chemist who made considerable contributions to organic chemistry. His research on aniline helped lay the basis of the aniline-dye industry, and his research on coal tar laid the g ...
at the
University of Berlin Humboldt-Universität zu Berlin (german: Humboldt-Universität zu Berlin, abbreviated HU Berlin) is a German public research university in the central borough of Mitte in Berlin. It was established by Frederick William III on the initiative ...
in 1875. There, he received his Ph.D. in 1878 under the supervision of
Ferdinand Tiemann Johann Karl Wilhelm Ferdinand Tiemann (June 10, 1848 – November 14, 1899) was a German chemist and together with Karl Reimer discoverer of the Reimer-Tiemann reaction. Beginning in 1866, Tiemann studied pharmacy at the TU Braunschweig wh ...
. Schotten stayed three years in the private laboratory of von Hofmann. In 1881, he was invited by
Emil du Bois-Reymond Emil Heinrich du Bois-Reymond (7 November 181826 December 1896) was a German physician and physiologist, the co-discoverer of nerve action potential, and the developer of experimental electrophysiology. Life Du Bois-Reymond was born in Berlin a ...
to become lecturer at the physiological institute at the University of Berlin. His analysis of
pyridine Pyridine is a basic heterocyclic organic compound with the chemical formula . It is structurally related to benzene, with one methine group replaced by a nitrogen atom. It is a highly flammable, weakly alkaline, water-miscible liquid with a ...
,
piperidine Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). It is a colorless liquid with an odor de ...
and
coniine Coniine is a poisonous chemical compound, an alkaloid present in and isolable from poison hemlock ('' Conium maculatum''), where its presence has been a source of significant economic, medical, and historico-cultural interest; coniine is also prod ...
paved the way for the determination of the structural relations within these three compounds.


Schotten-Baumann reaction

During his work at the physiological institute, Schotten, together with
Eugen Baumann Eugen Baumann (12 December 1846 – 3 November 1896) was a German chemist. He was one of the first people to create polyvinyl chloride (PVC), and, together with Carl Schotten, he discovered the Schotten-Baumann reaction. Life Baumann was born i ...
, discovered a method to synthesize
amide In organic chemistry, an amide, also known as an organic amide or a carboxamide, is a compound with the general formula , where R, R', and R″ represent organic groups or hydrogen atoms. The amide group is called a peptide bond when it i ...
s from
amine In chemistry, amines (, ) are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (), wherein one or more hydrogen Hydrogen is the chemical element wi ...
s and
acid chloride In organic chemistry, an acyl chloride (or acid chloride) is an organic compound with the functional group . Their formula is usually written , where R is a side chain. They are reactive derivatives of carboxylic acids (). A specific example o ...
s; this method is still known as the Schotten-Baumann reaction.*


Later life

Schotten stayed at Berlin University until 1891, when he changed to the imperial patent office. He held that position until his death in 1910.


References

{{DEFAULTSORT:Schotten, Carl 1853 births 1910 deaths 19th-century German chemists Leipzig University alumni Scientists from Marburg 20th-century German chemists