F-actin-capping protein subunit alpha-1 is a
protein that in humans is encoded by the ''CAPZA1''
gene.
CAPZA1 is a member of the
F-actin capping protein
In molecular biology, the F-actin capping protein is a protein complex which binds in a calcium-independent manner to the fast-growing ends of actin filaments (barbed end), thereby blocking the exchange of subunits at these ends. Unlike gelsolin a ...
alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein.
Function
The protein regulates growth of the
actin filament by capping the barbed end (plus-end) of growing actin filaments, preventing any further assembly from occurring.
This protein can be bound to the lipid
PIP2 preventing it from binding to actin filaments.
References
Further reading
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