Calculus Calculus, originally called infinitesimal calculus or "the calculus of infinitesimals", is the mathematical study of continuous change, in the same way that geometry is the study of shape, and algebra is the study of generalizations of arithm ...

bovis'', ''niu-huang'' (牛黃) or ox

bezoar A bezoar is a mass often found trapped in the gastrointestinal system, though it can occur in other locations. A pseudobezoar is an indigestible object introduced intentionally into the digestive system. There are several varieties of bezoar, s ...

s are dried

gallstone A gallstone is a calculus (medicine), stone formed within the gallbladder from precipitated bile components. The term cholelithiasis may refer to the presence of gallstones or to any disease caused by gallstones, and choledocholithiasis refers to ...

s of

cattle Cattle (''Bos taurus'') are large, domesticated, cloven-hooved, herbivores. They are a prominent modern member of the subfamily Bovinae and the most widespread species of the genus ''Bos''. Adult females are referred to as cows and adult mal ...

used in

Chinese herbology Chinese herbology () is the theory of traditional Chinese herbal therapy, which accounts for the majority of treatments in traditional Chinese medicine (TCM). A ''Nature'' editorial described TCM as "fraught with pseudoscience", and said that t ...

. In

China China, officially the People's Republic of China (PRC), is a country in East Asia. It is the world's most populous country, with a population exceeding 1.4 billion, slightly ahead of India. China spans the equivalent of five time zones and ...

and

Japan Japan ( ja, 日本, or , and formally , ''Nihonkoku'') is an island country in East Asia. It is situated in the northwest Pacific Ocean, and is bordered on the west by the Sea of Japan, while extending from the Sea of Okhotsk in the north ...

it has been long used to treat various diseases, including

high fever Fever, also referred to as pyrexia, is defined as having a temperature above the normal range due to an increase in the body's temperature set point. There is not a single agreed-upon upper limit for normal temperature with sources using val ...

, convulsion and

stroke A stroke is a medical condition in which poor blood flow to the brain causes cell death. There are two main types of stroke: ischemic, due to lack of blood flow, and hemorrhagic, due to bleeding. Both cause parts of the brain to stop functionin ...

. In

Asian Asian may refer to: * Items from or related to the continent of Asia: ** Asian people, people in or descending from Asia ** Asian culture, the culture of the people from Asia ** Asian cuisine, food based on the style of food of the people from Asi ...

countries, calculus bovis are sometimes harvested when

steer Steer, Steers or Steering may refer to: Animals * Steer or bullock, castrated male cattle * Ox, a steer used as a draft animal People * Steer (surname) * Steers (surname) Places * Steer Creek (West Virginia), a tributary of the Little ...

s (''Bos taurus domesticus'' Gmelin) are slaughtered. Their

gall bladder In vertebrates, the gallbladder, also known as the cholecyst, is a small hollow organ where bile is stored and concentrated before it is released into the small intestine. In humans, the pear-shaped gallbladder lies beneath the liver, although ...

s are taken out, the

bile Bile (from Latin ''bilis''), or gall, is a dark-green-to-yellowish-brown fluid produced by the liver of most vertebrates that aids the digestion of lipids in the small intestine. In humans, bile is produced continuously by the liver (liver bile ...

is filtered, and the stones are cleaned and dried. The bezoars may also be surgically removed by

veterinarians A veterinarian (vet), also known as a veterinary surgeon or veterinary physician, is a medical professional who practices veterinary medicine. They manage a wide range of health conditions and injuries in non-human animals. Along with this, vet ...

when working cattle become ill. In western countries, they are usually discarded. Its equivalent in

Vedic upright=1.2, The Vedas are ancient Sanskrit texts of Hinduism. Above: A page from the '' Atharvaveda''. The Vedas (, , ) are a large body of religious texts originating in ancient India. Composed in Vedic Sanskrit, the texts constitute the ...

culture is Gorochana. Calculus bovis have a color varying from golden yellow to brownish yellow. The shape of a stone is variable and depends on how it was formed, becoming spherical, oval, triangular, tubular, or irregular. Since natural calculus bovis are scarce, they can be very expensive. There are artificial calculus bovis or ''bovis calculus artifactus'' used as substitutes. In China, these are manufactured from

cholic acid Cholic acid, also known as 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid is a primary bile acid that is insoluble in water (soluble in alcohol and acetic acid), it is a white crystalline substance. Salts of cholic acid are called cholates. Ch ...

derived from bovine bile combined with dry bovine bile powder, porcine

ursodeoxycholic acid Ursodeoxycholic acid (UDCA), also known as ursodiol, is a secondary bile acid, produced in humans and most other species from metabolism by intestinal bacteria. It is synthesized in the liver in some species, and was first identified in bile of ...

taurine Taurine (), or 2-aminoethanesulfonic acid, is an organic compound that is widely distributed in animal tissues. It is a major constituent of bile and can be found in the large intestine, and accounts for up to 0.1% of total human body weight. It ...

bilirubin Bilirubin (BR) (Latin for "red bile") is a red-orange compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates. This catabolism is a necessary process in the body's clearance of waste products that arise from the ...

cholesterol Cholesterol is any of a class of certain organic molecules called lipids. It is a sterol (or modified steroid), a type of lipid. Cholesterol is biosynthesized by all animal cells and is an essential structural component of animal cell mem ...

, etc. Chinese regulations forbid the use of artificial calculus bovis in 42 drugs. Calculus bovis can cultivated (induced) ''

in vivo Studies that are ''in vivo'' (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and ...

'' by implanting a foreign object and microbials into bovine biles. It can also be cultivated (precipitated) ''

in vitro ''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology an ...

'' from bovine bile by adding ursodeoxycholic acid,

, and calcium bilirubinate, producing ''calculus bovis sativus''. Unlike artificial calculus bovis, either type of cultivated calculus bovis can fully replace calculus bovis under Chinese regulations.

References

External links

Niuhuang
*

Pharmacopoeia of the People's Republic of China A pharmacopoeia, pharmacopeia, or pharmacopoea (from the obsolete typography ''pharmacopœia'', meaning "drug-making"), in its modern technical sense, is a book containing directions for the identification of compound medicines, and published b ...

2015 entries for calculus bovis: *
Bovis calculus
≥ 5% cholic acid, ≥ 25% bilirubin by dry wright. *
Bovis calculus artifacus
artificial replacement produced from dry bovine bile. ≥ 13% cholic acid, ≥ 0.63% bilirubin by dry wright. *
Bovis calculus sativus
''in vitro'' cultivated replacement produced from bovine bile. ≥ 6% cholic acid, ≥ 35% bilirubin by dry wright. Traditional Chinese medicine Animal glandular products Cattle {{Pharm-stub