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Zydus Lifesciences Limited, formerly known as Cadila Healthcare Limited, is an Indian multinational
pharmaceutical A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field and re ...
company headquartered in
Ahmedabad Ahmedabad ( ; Gujarati: Amdavad ) is the most populous city in the Indian state of Gujarat. It is the administrative headquarters of the Ahmedabad district and the seat of the Gujarat High Court. Ahmedabad's population of 5,570,585 (per t ...
, which is primarily engaged in the manufacture of
generic drugs A generic drug is a pharmaceutical drug that contains the same chemical substance as a drug that was originally protected by chemical patents. Generic drugs are allowed for sale after the patents on the original drugs expire. Because the active ch ...
. It ranked 100th in the
Fortune India 500 The ''Fortune India'' 500 is a ranking of the top 500 corporations in India compiled on the basis of latest sales and gross revenue figures. The list is published annually by ''Fortune'' magazine. ''Fortune India'' is ''Fortune'' sixth internatio ...
list in 2020.


History

Cadila was founded in 1952 by
Ramanbhai Patel Ramanbhai B. Patel (19 August 1925 – 19 September 2001) was an Indian chemist who founded the operation, along with school friend I A Modi, that eventually became the Ahmedabad-based pharmaceutical company Cadila Laboratories. Patel was born ...
(1925–2001), formerly a lecturer in the L.M. College of Pharmacy, and his business partner
Indravadan Modi Indravadan Ambalal Modi (18 February 1926 – 26 November 2012) was an Indian pharmaceuticals industrialist who founded Cadila Pharmaceuticals in Ahmedabad. He is popularly known as the 'Medicine Man of India' for his contribution to the pharma ...
. It evolved over the next four decades into an established pharmaceutical company. In 1995 the Patel and Modi families split; the Modi family's share was moved into a new company called Cadila Pharmaceuticals Ltd., and Cadila Healthcare Ltd became the Patel family's holding company. Cadila Healthcare had its
initial public offering An initial public offering (IPO) or stock launch is a public offering in which shares of a company are sold to institutional investors and usually also to retail (individual) investors. An IPO is typically underwritten by one or more investment ...
on the
Bombay Stock Exchange BSE Limited, also known as the Bombay Stock Exchange (BSE), is an Indian stock exchange. It is located on Dalal Street in Mumbai. Established in 1875 by cotton merchant Premchand Roychand, a Jain businessman, it is the oldest stock exchange in ...
in 2000 as stock code 532321. In 2015 the company acquired another Indian pharmaceutical company called German Remedies. On 25 June 2007, the company acquired Química e Farmacêutica Nikkho do Brasil Ltda (Nikkho) as part of Zydus Healthcare Brasil Ltda. In 2010, Cadila Healthcare received a
Wellcome Trust The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of Glaxo ...
Award under the "R&D for Affordable Healthcare in India" initiative. In 2014, Cadila Healthcare launched the world's first '' adalimumab biosimilar'' under the brand name Exemptia at one-fifth the originator's price. Zydus Cadila Healthcare has also launched its first research based drug molecule Saroglitazar in treatment of Diabetic Dyslipidemia under brand name "Lipaglyn". SoviHep is the first sofosbuvir brand launched in India by Zydus in year 2015. In 2019, injectable
ketorolac Ketorolac, sold under the brand names Toradol, and Biorolac among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain. Specifically it is recommended for moderate to severe pain. Recommended duration of treatment is less ...
tromethamine manufactured by Zydus (Cadila Healthcare) was recalled due to microbial growth. In 2020, Zydus Cadila's drug Desidustat received approval by the
USFDA The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food s ...
to initiate clinical trials on
cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...
patients. In 2022 Cadila Healthcare Ltd., is renamed as Zydus Lifesciences Ltd.


Products

From twenty-five pharmaceutical production operations in India and Zydus Cadila develops and manufactures an extensive range of pharmaceuticals as well as diagnostics,
herbal A herbal is a book containing the names and descriptions of plants, usually with information on their medicinal, tonic, culinary, toxic, hallucinatory, aromatic, or magical powers, and the legends associated with them.Arber, p. 14. A herbal m ...
products, skincare products and other OTC products. Starting from late 2015, having concluded a voluntary license agreement with
Gilead Gilead or Gilad (; he, גִּלְעָד ''Gīləʿāḏ'', ar, جلعاد, Ǧalʻād, Jalaad) is the ancient, historic, biblical name of the mountainous northern part of the region of Transjordan.''Easton's Bible Dictionary'Galeed''/ref> Th ...
, the company also produces the generics for
hepatitis C Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver; it is a type of viral hepatitis. During the initial infection people often have mild or no symptoms. Occasionally a fever, dark urine, a ...
treatment (i.e.
sofosbuvir Sofosbuvir, sold under the brand name Sovaldi among others, is a medication used to treat hepatitis C. It is taken Oral administration, by mouth. Common side effects include fatigue, headache, nausea, and trouble sleeping. Side effects are gen ...
, distributed under the brand name SoviHep). The company makes
active pharmaceutical ingredient An active ingredient is any ingredient that provides biologically active or other direct effect in the diagnosis, cure, mitigation, treatment, or prevention of disease or to affect the structure or any function of the body of humans or animals. The ...
s at three sites in India, Ankleshwar plants, Vadodara plant, and Patalganga plant.


COVID-19 vaccine development

In July 2020, the company got permission to conduct human trials of the developmental COVID-19 vaccine named
ZyCoV-D ZyCoV-D is a DNA vaccine, DNA plasmid-based COVID-19 vaccine developed by Indian pharmaceutical company Cadila Healthcare, with support from the Biotechnology Industry Research Assistance Council. It is emergency use authorisation, approved ...
, from the
Drugs Controller General of India Drugs Controller General of India (DCGI) is the head of department of the Central Drugs Standard Control Organization of the Government of India responsible for approval of licences of specified categories of drugs such as blood and blood p ...
(DCGI), Government of India. On 20 August 2021, DCGI granted emergency use approval of ZyCoV-D. Cadila is also among the several Indian pharma companies that received the licensing agreements from the
Gilead Sciences Gilead Sciences, Inc. () is an American biopharmaceutical company headquartered in Foster City, California, that focuses on researching and developing antiviral drugs used in the treatment of HIV/AIDS, hepatitis B, hepatitis C, influenza, and CO ...
to produce ''
remdesivir Remdesivir, sold under the brand name Veklury, Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged. is a broad-spectrum antiviral medication developed by the ...
''.


Corporate control

Zydus Cadila's major shareholder remains the Patel family.
Pankaj Patel Pankaj Ramanbhai Patel (born 1952/1953) is an Indian billionaire businessman, and the chairman of Zydus Lifesciences, the fifth largest pharmaceutical company in India. Early life Pankaj Patel is a Gujarati. Patel holds Bachelor of Pharmacy and ...
(born 1953), son of the founder, is the chairman of the company. In 2004, Pankaj Patel was included in '' Forbes''' annual list of India's richest people. As of 2020, ''Forbes'' estimates Patel's net worth at US $3.9 billion, making him India's 46th richest person.


References


External links

* {{Authority control Pharmaceutical companies of India Manufacturing companies based in Ahmedabad Health care companies of India Pharmaceutical companies established in 1952 1952 establishments in Bombay State Indian companies established in 1952 Companies listed on the National Stock Exchange of India Companies listed on the Bombay Stock Exchange COVID-19 vaccine producers Companies based in Ahmedabad