CXO may refer to:
*
Chandra X-ray Observatory, a satellite launched by NASA in 1999
*
Chief experience officer, corporate officer responsible for the overall user experience of an organization
*CxO (Chief-"x"-officer), also called
C-suite, a generic term for any corporate officer
*
CrossOver (software), a commercial version of WINE which runs Windows applications on Linux, Mac OS X and Solaris
*
Lone Star Executive Airport, the airport in Conroe, Texas, United States (IATA code)
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