Chemokine (C-X-C motif) ligand 17 (CXCL17) is a small

cytokine Cytokines are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Cytokines are peptides and cannot cross the lipid bilayer of cells to enter the cytoplasm. Cytokines have been shown to be involved in autocrin ...

belonging to the CXC

chemokine Chemokines (), or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells. In additio ...

family that has been identified in humans and mice. CXCL17 attracts dendritic cells and monocytes and is regulated in tumors. It is also known as ''VEGF co-regulated chemokine 1 (VCC-1)'' and ''dendritic cell- and monocyte-attracting chemokine-like protein'' (DMC). This chemokine is constitutively expressed in the lung. The gene for human CXCL17 is located on

chromosome 19 Chromosome 19 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 19 spans more than 58.6 million base pairs, the building material of DNA. It is considered the most gene-rich chromosome ...

. CXCL17 is an orphan chemokine with no known receptor.

Receptor

The receptor for CXCL17 is likely to be a

G protein-coupled receptor G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...

(GPCR). The GPCR GPR35 was thought to be a receptor of CXCL17. Subsequent research has suggested that GPR35 is not a receptor for CXCL17.

References

Cytokines {{gene-19-stub