CREB regulated transcription coactivator 2, also known as CRTC2, is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
which in humans is encoded by the CRTC2
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
CRTC2, initially called TORC2, is a transcriptional
coactivator
A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes. The activator contains a DNA binding domain that binds either to a DNA p ...
for the transcription factor
CREB
CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first des ...
and a central regulator of
gluconeogenic gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. The ...
in response to
cAMP
Camp may refer to:
Outdoor accommodation and recreation
* Campsite or campground, a recreational outdoor sleeping and eating site
* a temporary settlement for nomads
* Camp, a term used in New England, Northern Ontario and New Brunswick to descri ...
.
CRTC2 is thought to drive tumorigenesis in LKB11/STK11-null non-small cell lung cancers (
NSCLC).
Interactions
CRTC2 has been shown to
interact
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with
SNF1LK2
Serine/threonine-protein kinase SIK2 is an enzyme that in humans is encoded by the ''SIK2'' gene.
Interactions
SNF1LK2 has been shown to interact with CRTC2
CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which ...
and
YWHAQ
14-3-3 protein theta is a protein that in humans is encoded by the ''YWHAQ'' gene.
Function
This gene product belongs to the 14-3-3 family of proteins that mediate signal transduction by binding to phosphoserine-containing proteins. This highl ...
.
References
Further reading
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External links
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Gene expression
Transcription coregulators
{{gene-1-stub