CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (''T''ransducer ''O''f ''R''egulated ''C''REB activity ''1''), is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the ''CRTC1''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands
and various regions of the adult central nervous system.
Clinical significance
Production of CRTC1 is blocked in
Alzheimer's disease.
See also
*
Transcription coregulator
In molecular biology and genetics, transcription coregulators are proteins that interact with transcription factors to either activate or repress the transcription of specific genes. Transcription coregulators that activate gene transcription ar ...
References
Further reading
*
*
*
*
*
*
*
*
*
*
*
*
*
External links
*
*
Gene expression
Transcription coregulators
Immunology
Alzheimer's disease research
{{gene-19-stub