Crk-like protein is a
protein that in humans is encoded by the
CRKL gene.
Function
v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential.
CrkL together with
Crk
Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the ''CRK'' gene.
The CRK protein participates in the Reelin signaling cascade downstream of DAB1.
Function
Adapter molecule crk is a member of ...
participates in the
Reelin signaling cascade downstream of
DAB1.
Interactions
CRKL has been shown to
interact with:
*
Abl gene,
* BCAR1,
* BCR gene,
* CBLB,
* CD117,
* CD34,
* Cbl gene,
* Dock2
Dock2 (Dedicator of cytokinesis 2), also known as DOCK2, is a large (~180 kDa) protein involved in intracellular signalling networks. It is a member of the DOCK-A subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which ...
,
* EPOR,
* GAB1,[
* GAB2,]
* INPP5D,[
* MAP4K1,]
* MAP4K5,
* NEDD9,
* PIK3R2
Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the ''PIK3R2'' gene.
A recent study on gene expression indicated that the PIK3R2 gene might have a key role in pan-cancer prognosis.
Interactions
...
,[
* Paxillin]
* RAPGEF1,
* RICS,
* STAT5A,
* Syk, and
* WAS
Was or WAS may refer to:
* ''Was'', a past-tense form of the English copular verb ''to be''
People
* David Was (born c. 1952), the stage name of multi-instrumentalist and songwriter David Weiss
* Don Was (born 1952), the stage name of bass gui ...
.[
]
See also
*Crk
Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the ''CRK'' gene.
The CRK protein participates in the Reelin signaling cascade downstream of DAB1.
Function
Adapter molecule crk is a member of ...
References
Further reading
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External links
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{{PDB Gallery, geneid=1399