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Crk-like protein is a protein that in humans is encoded by the CRKL gene.


Function

v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential. CrkL together with
Crk Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the ''CRK'' gene. The CRK protein participates in the Reelin signaling cascade downstream of DAB1. Function Adapter molecule crk is a member of ...
participates in the Reelin signaling cascade downstream of DAB1.


Interactions

CRKL has been shown to interact with: * Abl gene, * BCAR1, * BCR gene, * CBLB, * CD117, * CD34, * Cbl gene, *
Dock2 Dock2 (Dedicator of cytokinesis 2), also known as DOCK2, is a large (~180 kDa) protein involved in intracellular signalling networks. It is a member of the DOCK-A subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which ...
, * EPOR, * GAB1, * GAB2, * INPP5D, * MAP4K1, * MAP4K5, * NEDD9, *
PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the ''PIK3R2'' gene. A recent study on gene expression indicated that the PIK3R2 gene might have a key role in pan-cancer prognosis. Interactions ...
, * Paxillin * RAPGEF1, * RICS, * STAT5A, * Syk, and *
WAS Was or WAS may refer to: * ''Was'', a past-tense form of the English copular verb ''to be'' People * David Was (born c. 1952), the stage name of multi-instrumentalist and songwriter David Weiss * Don Was (born 1952), the stage name of bass gui ...
.


See also

*
Crk Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the ''CRK'' gene. The CRK protein participates in the Reelin signaling cascade downstream of DAB1. Function Adapter molecule crk is a member of ...


References


Further reading

* * * * * * * * * * * * * * * * * *


External links

* {{PDB Gallery, geneid=1399