The cation:proton antiporter (CPA) superfamily is a
superfamily
SUPERFAMILY is a database and search platform of structural and functional annotation for all proteins and genomes. It classifies amino acid sequences into known structural domains, especially into SCOP superfamilies. Domains are functional, str ...
of
transport proteins named after one of its constituent members, the
monovalent cation:proton antiporter-2 (CPA2).
was considered a member of the superfamily until 2010, when it was discovered to in fact be a member of the
VIC
Vic (; es, Vic or Pancracio Celdrán (2004). Diccionario de topónimos españoles y sus gentilicios (5ª edición). Madrid: Espasa Calpe. p. 843. ISBN 978-84-670-3054-9. «Vic o Vich (viquense, vigitano, vigatán, ausense, ausetano, ausonense): ...
superfamily. As of April 2016, the CPA superfamily consists of four members:
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Monovalent cation:proton antiporter-2 family
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Malonate:Sodium symporter family
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Putative sulfate exporter family
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Sodium-transporting carboxylic acid decarboxylase family
Structural variation exists between families. For example, members of the CPA2 family are between 300 and 900 amino acyl residues (aas) in length and exhibit 10 to 14 transmembrane segments (TMSs), while members of the MSS family are shorter than 300 aas and exhibit 4 to 7 TMSs.
See also
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Transporter Classification Database
Further reading
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References
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Membrane proteins
Transmembrane proteins
Transmembrane transporters
Transport proteins
Integral membrane proteins
Protein superfamilies