Coronin, actin binding protein, 1B also known as CORO1B is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
which in humans is encoded by the ''CORO1B''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Members of the
coronin family, such as CORO1B, are
WD repeat-containing
actin
Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. It is found in essentially all eukaryotic cells, where it may be present at a concentration of over ...
-binding proteins that regulate
cell motility
Motility is the ability of an organism to move independently, using metabolic energy.
Definitions
Motility, the ability of an organism to move independently, using metabolic energy, can be contrasted with sessility, the state of organisms th ...
.
Function
A mammalian
coronin enriches at the leading edge of migrating cells.
Studies related to this protein are as follows:
* Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia.
* F-actin binding is essential for coronin 1B function in vivo.
* Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.
* Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.
* In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury.
* Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway.
References
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