Conserved oligomeric Golgi complex subunit 8 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''COG8''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Multiprotein complexes
Protein quaternary structure is the fourth (and highest) classification level of protein structure. Protein quaternary structure refers to the structure of proteins which are themselves composed of two or more smaller protein chains (also refe ...
are key determinants of
Golgi apparatus
The Golgi apparatus (), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells. Part of the endomembrane system in the cytoplasm, it packages proteins into membrane-bound vesicles ins ...
structure and its capacity for
intracellular transport
Intracellular transport is the movement of vesicles and substances within a cell. Intracellular transport is required for maintaining homeostasis within the cell by responding to physiological signals. Proteins synthesized in the cytosol are dist ...
and
glycoprotein
Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycos ...
modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in
glycosylation
Glycosylation is the reaction in which a carbohydrate (or ' glycan'), i.e. a glycosyl donor, is attached to a hydroxyl or other functional group of another molecule (a glycosyl acceptor) in order to form a glycoconjugate. In biology (but not al ...
reactions, and the SEC34 complex, which is involved in
vesicular transport. These 3 complexes are identical and have been termed the
conserved oligomeric Golgi complex The Conserved oligomeric Golgi complex (COG) is a multiprotein complex found in the Golgi apparatus structure and involved in intracellular transport and glycoprotein modification.
Earlier names for this complex were : the Golgi transport complex ( ...
(COG), which includes COG8 (Ungar et al., 2002).
upplied by OMIMref name="entrez" />
References
Further reading
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External links
GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview*
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