Conserved oligomeric Golgi complex subunit 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''COG1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans-Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex.
Interactions
COG1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
COG4
Conserved oligomeric Golgi complex subunit 4 is a protein that in humans is encoded by the ''COG4'' gene.
Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modif ...
and
COG3
Conserved oligomeric Golgi complex subunit 3 is a protein that in humans is encoded by the ''COG3'' gene.
The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized o ...
.
References
Further reading
*
*
*
*
*
*
*
*
*
External links
GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview*
{{gene-17-stub