CCR4-NOT transcription complex subunit 8 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''CNOT8''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
It is a subunit of the
CCR4-Not
Carbon Catabolite Repression—Negative On TATA-less, or CCR4-Not, is a multiprotein complex that functions in gene expression. The complex has multiple enzymatic activities as both a poly(A) 3′-5′ exonuclease and a ubiquitin ligase. The com ...
deadenylase complex.
Interactions
CNOT8 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
BTG2
Protein BTG2 also known as BTG family member 2 or NGF-inducible anti-proliferative protein PC3 or NGF-inducible protein TIS21, is a protein that in humans is encoded by the ''BTG2'' gene (B-cell translocation gene 2) and in other mammals by the ho ...
,
BTG1
Protein BTG1 is a protein that in humans is encoded by the ''BTG1'' gene.
Function
The BTG1 gene locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. It is a memb ...
,
CNOT1
CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the ''CNOT1'' gene.
It is a part of the CCR4-Not complex, which deadenylates mRNAs. CNOT1 acts as a scaffold protein, binding other subunits of the complex.
I ...
CNOT3
CCR4-NOT transcription complex subunit 3 is a protein that in humans is encoded by the ''CNOT3'' gene. It is a subunit of the CCR4-Not deadenylase complex.
Interactions
CNOT3 has been shown to interact with CNOT8
CCR4-NOT transcription com ...
.[
]
References
Further reading
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External links
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