CMX521 is an
antiviral drug discovered by Chimerix, which was developed for the treatment of
norovirus, though it also shows efficacy against related viral diarrheas such as
rotovirus
''Rotavirus'' is a genus of double-stranded RNA viruses in the family ''Reoviridae''. Rotaviruses are the most common cause of diarrhoeal disease among infants and young children. Nearly every child in the world is infected with a rotavirus at ...
and some
sapoviruses,
astroviruses and
adenovirus
Adenoviruses (members of the family ''Adenoviridae'') are medium-sized (90–100 nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double-stranded DNA genome. Their name derives from the ...
es. It is a
nucleoside analogue which acts as an inhibitor of viral RNA-dependant RNA
polymerase
A polymerase is an enzyme ( EC 2.7.7.6/7/19/48/49) that synthesizes long chains of polymers or nucleic acids. DNA polymerase and RNA polymerase are used to assemble DNA and RNA molecules, respectively, by copying a DNA template strand using base- ...
.
See also
*
GS-441524
*
NITD008
NITD008 is an antiviral drug classified as an adenosine analog (a type of nucleoside analog). It was developed as a potential treatment for flavivirus infections and shows broad spectrum antiviral activity against many related viruses such as d ...
*
Sangivamycin
Sangivamycin is a natural product originally isolated from ''Streptomyces rimosus'', which is a nucleoside analogue. It acts as an inhibitor of protein kinase C. It has antibiotic, antiviral and anti-cancer properties and has been investigated ...
References
Anti–RNA virus drugs
Antiviral drugs
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