Calcineurin B homologous protein 1 is a protein encoded in humans by the ''CHP1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
(formerly ''CHP'').
Function
The protein encoded by this gene is a
phosphoprotein
A phosphoprotein is a protein that is posttranslationally modified by the attachment of either a single phosphate group, or a complex molecule such as 5'-phospho-DNA, through a phosphate group. The target amino acid is most often serine, threonin ...
that binds to the sodium-hydrogen exchangers (NHEs). This protein serves as an essential
cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of
calcineurin
Calcineurin (CaN) is a calcium and calmodulin dependent serine/threonine protein phosphatase (also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase). It activates the T cells of the immune system and can be block ...
activity.
Interactions
Calcineurin B homologous protein 1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
*
sodium-hydrogen antiporter 1,
*
sodium-hydrogen antiporter 3,
[ and
* sodium-hydrogen anti porter 9.]
References
Further reading
*
*
*
*
*
*
*
*
*
*
*
*
*
External links
*
{{gene-15-stub
EF-hand-containing proteins