CGS-21680 is a specific
adenosine
Adenosine ( symbol A) is an organic compound that occurs widely in nature in the form of diverse derivatives. The molecule consists of an adenine attached to a ribose via a β-N9-glycosidic bond. Adenosine is one of the four nucleoside building ...
A2A subtype receptor
agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
. It is usually presented as an organic hydrochloride salt with a molecular weight of 536.0 g/''M''. It is soluble up to 3.4 mg/mL in
DMSO
Dimethyl sulfoxide (DMSO) is an organosulfur compound with the formula ( CH3)2. This colorless liquid is the sulfoxide most widely used commercially. It is an important polar aprotic solvent that dissolves both polar and nonpolar compounds an ...
and 20 mg/mL in 45% (w/v) ''aq'' 2-hydroxypropyl-β-cyclodextrin.
The chemical is currently used by researchers interested in studying neuronal transmission with a high-affinity, subtype specific analogue for adenosine. This includes research in respiration where it is believed that A
2A receptors are involved in rhythm generation in the
pre-Bötzinger complex The preBötzinger complex, sometimes written pre-Bötzinger complex (preBötC), is a functionally and anatomically specialized site in the ventral-lateral region of the lower medulla oblongata (i.e., lower brainstem). The preBötC is part of the ven ...
. The drug is not currently approved for use in a therapeutic capacity.
See also
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Adenosine receptor
The adenosine receptors (or P1 receptors) are a class of purinergic G protein-coupled receptors with adenosine as the endogenous ligand. There are four known types of adenosine receptors in humans: A1, A2A, A2B and A3; each is encoded by a di ...
References
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Nucleosides
Purines
Carboxamides
Adenosine receptor agonists
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