CGP-37849 is a competitive
antagonist at the
NMDA receptor. It is a potent, orally active
anticonvulsant in animal models, and was researched for the treatment of
epilepsy
Epilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures. Epileptic seizures can vary from brief and nearly undetectable periods to long periods of vigorous shaking due to abnormal electrica ...
. It also has
neuroprotective
Neuroprotection refers to the relative preservation of neuronal structure and/or function. In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal los ...
activity and shows
antidepressant and
anxiolytic
An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxiet ...
effects.
References
{{Ionotropic glutamate receptor modulators
NMDA receptor antagonists
Phosphonic acids
Amino acids
Alkene derivatives