Corneodesmosin is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''CDSN''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
This gene encodes a protein found in corneodesmosomes, which localize to the human epidermis and other cornified squamous epithelia. During maturation of the cornified layers, the protein undergoes a series of cleavages, which are thought to be required for
desquamation
Desquamation occurs when the outermost layer of a tissue, such as the skin, is shed. The term is . Physiologic desquamation
Keratinocytes are the predominant cells of the epidermis, the outermost layer of the skin. Living keratinocytes reside in ...
. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.
See also
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Hypertrichosis simplex of the scalp
Hypertrichosis simplex of the scalp is a cutaneous condition caused by defects in the corneodesmosin protein.
See also
* Hairy elbow syndrome
* List of cutaneous conditions
* List of conditions caused by problems with junctional proteins
M ...
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References
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{{gene-6-stub
Plakins