The CDGSH iron sulfur domain are a group of
iron-sulfur (2Fe-2S) clusters and a unique 39 amino acid CDGSH domain
''C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H
The CDGSH iron sulfur domain 1 protein (also referred to as mitoNEET) is an
integral membrane protein
An integral, or intrinsic, membrane protein (IMP) is a type of membrane protein that is permanently attached to the biological membrane. All ''transmembrane proteins'' are IMPs, but not all IMPs are transmembrane proteins. IMPs comprise a sign ...
located in the
outer mitochondrial membrane
A mitochondrion (; ) is an organelle found in the cells of most Eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is use ...
and whose function may be to transport iron into the mitochondria.
Iron in turn is essential for the function of several mitochondrial
enzymes.
The
antidiabetic drug
pioglitazone
Pioglitazone, sold under the brand name Actos among others, is an anti-diabetic medication used to treat type 2 diabetes. It may be used with metformin, a sulfonylurea, or insulin. Use is recommended together with exercise and diet. It is not re ...
, in addition to binding to the
nuclear receptor PPAR, also has been shown to bind mitoNEET with approximately equal affinity.
References
External links
* {{MeshName, ZCD1+protein,+human
Protein domains