CD49d is an
integrin
Integrins are transmembrane receptors that facilitate cell-cell and cell-extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, ...
alpha subunit. It makes up half of the α4β1
lymphocyte homing receptor Lymphocyte homing receptors are cell adhesion molecules expressed on lymphocyte cell membranes that recognize addressins on target tissues. ''Lymphocyte homing'' refers to adhesion of the circulating lymphocytes in blood to specialized endothelial c ...
.
Function
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.
Interactions
CD49d has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
LGALS8
Galectin-8 is a protein of the galectin family that in humans is encoded by the ''LGALS8'' gene.
Function
This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate rec ...
and
Paxillin
Paxillin is a protein that in humans is encoded by the ''PXN'' gene. Paxillin is expressed at focal adhesions of non-striated cells and at costameres of striated muscle cells, and it functions to adhere cells to the extracellular matrix. Mutation ...
.
See also
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Carotegrast methyl
Carotegrast methyl (trade name Carogra) is a drug used for the treatment of ulcerative colitis.
Carotegrast methyl is a prodrug that has little pharmacological activity itself. The methyl ester, which is designed to enhance oral bioavailability ...
, an integrin alpha 4 antagonist used for the treatment of ulcerative colitis
References
Further reading
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External links
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ITGA4Info with links in th
Cell Migration Gateway
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Integrins
Clusters of differentiation
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