CD120 (Cluster of Differentiation 120) can refer to two members of the
tumor necrosis factor receptor
The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine-rich domain. With the exception of nerve grow ...
superfamily:
tumor necrosis factor receptor 1
Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and CD120a, is a ubiquitous membrane receptor that binds tumor necrosis factor-alpha (TNFα).
Function
The protein encoded b ...
(TNFR1) and
tumor necrosis factor receptor 2
Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and CD120b, is one of two membrane receptors that binds tumor necrosis factor-alpha (TNFα). Like its counterpart, tumor necro ...
(TNFR2).
Receptor subtypes
There are two variants of the receptor, each encoded by a separate gene:
* CD120a - TNFR1 - TNFR superfamily member 1A
* CD120b - TNFR2 - TNFR superfamily member 1B
TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,
and is involved in neurotoxic processes.
Elevated levels of TNFR1 has been found in severe mental disorders.
Signaling pathway
See also
*
Cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophen ...
References
External links
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{{Cytokine receptor modulators