In genetics, Rs1805054, also called C267T, is a name used for a specific genetic variation, a

single nucleotide polymorphism In genetics, a single-nucleotide polymorphism (SNP ; plural SNPs ) is a germline substitution of a single nucleotide at a specific position in the genome. Although certain definitions require the substitution to be present in a sufficiently larg ...

(SNP), in the

HTR6 The 5HT6 receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT). It is a G protein-coupled receptor (GPCR) that is coupled to G(s)alpha, Gs and mediates Excitatory postsynaptic pote ...

gene. It is one of the few investigated polymorphisms of its gene. C267T is a

synonymous polymorphism A synonymous substitution (often called a ''silent'' substitution though they are not always silent) is the evolutionary substitution of one base for another in an exon of a gene coding for a protein, such that the produced amino acid sequence i ...

. As of 2008 meta-analysis of the polymorphism and

Alzheimer's disease Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term me ...

indicates that there probably is no association between the two, though individual studies report such an association, e.g., a Chinese study found an association with late-onset Alzheimer's disease. Another reported association in neuropsychiatry disorders is with treatment response in depression. C267T has also been examined in relation to personality traits, with a Korean study finding some evidence for an association with the trait '' self-transcendence''. A Japanese study reported no association with personality traits using the

NEO PI-R The Revised NEO Personality Inventory (NEO PI-R) is a personality inventory that assesses an individual on five dimensions of personality, the so-called Big Five personality traits. These traits are openness to experience, conscientiousness, ext ...

personality inventory.

References

{{Reflist SNPs on chromosome 1