Carroll Lockard "Lock" Conley (May 14, 1915 – January 30, 2010) was a
hematologist
Hematology (American and British English spelling differences#ae and oe, always spelled haematology in British English) is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to ...
and founder of the Division of Hematology at the
Johns Hopkins School of Medicine
The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Founded in 1893, the School of Medicine shares a campus with the Johns Hopkins Hospi ...
.
Early life and education
Conley was born in
Baltimore, Maryland
Baltimore ( , locally: or ) is the List of municipalities in Maryland, most populous city in the U.S. state of Maryland, fourth most populous city in the Mid-Atlantic (United States), Mid-Atlantic, and List of United States cities by popula ...
. His father owned The Leib Packing Co., an oyster packing firm, and his mother was a homemaker. He attended
Forest Park High School, graduating in 1931. He then attended
Johns Hopkins University
Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hem ...
, graduating with a degree in biology. He attended the
University of Maryland School of Medicine
The University of Maryland School of Medicine (abbreviated UMSOM), located in Baltimore City, Maryland, U.S., is the medical school of the University of Maryland, Baltimore and is affiliated with the University of Maryland Medical Center and Me ...
, then transferred to the
Columbia University College of Physicians and Surgeons
Columbia University Vagelos College of Physicians and Surgeons (VP&S) is the graduate medical school of Columbia University, located at the Columbia University Irving Medical Center in the Washington Heights neighborhood of Manhattan. Founded i ...
, receiving his M.D. degree in 1940. He interned at
NewYork–Presbyterian Hospital The NewYork-Presbyterian Hospital is a nonprofit academic medical center in New York City affiliated with two Ivy League medical schools, Cornell University and Columbia University. The hospital comprises seven distinct campuses located in the New Y ...
, then entered the
U.S. Army Medical Corps, serving throughout World War II and leaving the Army with the rank of major.
Career
He joined the faculty of Johns Hopkins Medical School in 1946, and the next year he was appointed head of the newly formed Division of Hematology. He was appointed a full professor in 1956 and a Distinguished Professor of Medicine in 1976.
He remained at Hopkins until his retirement in 1980. He then was appointed distinguished senior clinician at the
U.S. Public Health Service Hospital in Baltimore, where he established a teaching program for medical students. He retired from that position in 1987.
His hematology research included important work on blood coagulation, blood platelets, hemorrhagic diseases, and hemoglobins. He made significant contributions to developing a therapy for
vitamin B-12
Vitamin B12, also known as cobalamin, is a water-soluble vitamin involved in metabolism. It is one of eight B vitamins. It is required by animals, which use it as a cofactor in DNA synthesis, in both fatty acid and amino acid metabolism. It ...
deficiency.
In 1947 he discovered and described
lupus anticoagulant
Lupus anticoagulant is an immunoglobulin that binds to phospholipids and proteins associated with the cell membrane. Its name is a partial misnomer, as it is actually a prothrombotic antibody ''in vivo''. Lupus anticoagulant in living systems cause ...
s.
In 1953 he and a research fellow, Ernest W. Smith, described a simple method of separating the components of
hemoglobin
Hemoglobin (haemoglobin BrE) (from the Greek word αἷμα, ''haîma'' 'blood' + Latin ''globus'' 'ball, sphere' + ''-in'') (), abbreviated Hb or Hgb, is the iron-containing oxygen-transport metalloprotein present in red blood cells (erythrocyte ...
on filter paper using
electrophoresis
Electrophoresis, from Ancient Greek ἤλεκτρον (ḗlektron, "amber") and φόρησις (phórēsis, "the act of bearing"), is the motion of dispersed particles relative to a fluid under the influence of a spatially uniform electric fie ...
, which made hemoglobin analysis far more widely available and facilitated the study and treatment of
sickle cell anemia
Sickle cell disease (SCD) is a group of blood disorders typically inherited from a person's parents. The most common type is known as sickle cell anaemia. It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blo ...
. In his studies of sickle cell anemia he followed some patients for 40 years.
He was universally described as an inspiring teacher, and many of his students and fellows went on to become university chancellors, medical department chairs, and heads of hematology divisions. When he retired in 1980, a whole issue of the Johns Hopkins Medical Journal was devoted to him, consisting entirely of articles by his former students. In 2002 Sir
David Weatherall
Sir David John Weatherall, (9 March 1933 – 8 December 2018) was a British physician and researcher in molecular genetics, haematology, pathology and clinical medicine.
Early life and education
David Weatherall was born in Liverpool.Geoff Wa ...
and three other former students dedicated their book ''Haematology'' to Conley, of whom Weatherall said “Of all the remarkable physicians with whom I have had the privilege of associating over the years, I can think of no one who had more influence on the way I came to think about patient care and medical research.”
He served as president of the American Society of Hematology in 1976.
Personal
He was married to the former Edith Martina DeYoung, a registered nurse, for 62 years until her death in 2005. They had two daughters.
Recognition
* The
American College of Physicians
The American College of Physicians (ACP) is a national organization of internists, who specialize in the diagnosis, treatment, and care of adults.Sokanu "What is an Internist?" Retrieved October 20, 2014 With 161,000 members, ACP is the largest ...
honors his skill as a teacher by awarding an annual C. Lockard Conley, M.D. Award for Excellence in Medical Resident Education.
* The C. Lockard Conley Fellowship Award in Hematology is given to a medical student at Johns Hopkins Medical School.
* His collected papers are housed at the Medical Archives of the Johns Hopkins Medical Institutions.
References
{{DEFAULTSORT:Conley, C. Lockard
American hematologists
Johns Hopkins University faculty
Johns Hopkins Hospital physicians
Johns Hopkins University alumni
Columbia University Vagelos College of Physicians and Surgeons alumni
Physicians from Baltimore
1915 births
2010 deaths
Presidents of the American Society of Hematology