Betty Mack Twarog (August 28, 1927 – February 6, 2013) was an American

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...

who was the first to find

serotonin Serotonin () or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Its biological function is complex and multifaceted, modulating mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vas ...

in mammalian brain.

Life and career

Betty M Twarog was born on August 28, 1927, in New York City. She attended

Swarthmore College Swarthmore College ( , ) is a Private college, private Liberal arts colleges in the United States, liberal arts college in Swarthmore, Pennsylvania. Founded in 1864, with its first classes held in 1869, Swarthmore is one of the earliest coeduca ...

from 1944 to 1948, focusing on mathematics. While studying for an M.Sc. at Tufts College she heard a lecture on mollusc muscle neurology and in 1949 enrolled under

John Welsh John Welsh may refer to: *John Welsh of Ayr (1568–1622), religious leader *John Welsh of Irongray, religious leader *John Welsh (actor) (1904–1985), Irish actor *John Welsh (Australian footballer) (born 1938), Australian rules football player f ...

in the PhD program at Harvard to study this area. By 1952 she had submitted a paper showing that serotonin had a role as a neurotransmitter in mussels. In autumn 1952 Twarog moved for family reasons to the Kent State University area, and chose the Cleveland Clinic as a place to continue her study of her hypothesis that invertebrate neurotransmitters would also be found in mammals. Although her supporter there,

Irvine Page Irvine Heinly Page (January 7, 1901 – June 10, 1991) was an American physiologist who played an important part in the field of hypertension for almost 60 years while working at the Cleveland Clinic as the first Chair of Research.Frohlich ED, D ...

did not believe serotonin would be found in the brain, he nevertheless gave Twarog a laboratory and technician. By June 1953 a paper was submitted announcing the isolation of serotonin in mammalian brain. Twarog left the Cleveland Clinic in 1954 and continued to work on invertebrate smooth muscle at Tufts, Harvard and SUNY at Stony Brook. In later years, at the Bigelow Laboratory for Ocean Sciences in Boothbay Harbor, Maine, she worked on how shellfish evade

phytoplankton Phytoplankton () are the autotrophic (self-feeding) components of the plankton community and a key part of ocean and freshwater ecosystems. The name comes from the Greek words (), meaning 'plant', and (), meaning 'wanderer' or 'drifter'. Ph ...

poisons. Twarog died on February 6, 2013, at the age of 85 in

Damariscotta, Maine Damariscotta (/ dæmrɪˈskɒtə/ ) is a town in Lincoln County, Maine, United States. The population was 2,297 at the 2020 census. Damariscotta is the oyster capital of New England. A popular tourist destination, the towns of Damariscotta and N ...

Impact in science and medicine

Twarog's isolation of serotonin in brain established its potential as a neurotransmitter and thus a modulator of brain action. Her discovery was an essential precursor to the creation in 1978 of the antidepressant

SSRI Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs increase the extracellul ...

medicines such as

fluoxetine Fluoxetine, sold under the brand names Prozac and Sarafem, among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used for the treatment of major depressive disorder, obsessive–compulsive disorde ...

and

sertraline Sertraline, sold under the brand name Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. The efficacy of sertraline for depression is similar to that of other antidepressants, and the differe ...

References

{{DEFAULTSORT:Twarog, Betty American women biochemists Harvard University alumni 1927 births 2013 deaths Swarthmore College alumni People from Damariscotta, Maine Tufts University School of Arts and Sciences alumni 21st-century American women