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Bertold Paul Wiesner (1901–1972) was an
Austrian Austrian may refer to: * Austrians, someone from Austria or of Austrian descent ** Someone who is considered an Austrian citizen, see Austrian nationality law * Austrian German dialect * Something associated with the country Austria, for example: ...
Jew Jews ( he, יְהוּדִים, , ) or Jewish people are an ethnoreligious group and nation originating from the Israelites Israelite origins and kingdom: "The first act in the long drama of Jewish history is the age of the Israelites""T ...
ish
physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemica ...
noted firstly for coining the term 'Psi' to denote
parapsychological Parapsychology is the study of alleged psychic phenomena (extrasensory perception, telepathy, precognition, clairvoyance, psychokinesis (also called telekinesis), and psychometry) and other paranormal claims, for example, those related to near- ...
phenomena;Rhine, J. B., 'Psi Phenomena and Psychiatry'. Proceedings of the Royal Society of Medicine 43 (11) (1950) pp804–814.Thouless, R. H. and Wiesner, B. P., 'The Psi Processes in Normal and Paranormal Psychology'. Proceedings of the Society for Psychical Research 48 (1948) pp177-196.Thouless, R. H. and Wiesner, B. P., 'On the Nature of Psi Phenomena'. Journal of Parapsychology Vol 1. (1946) pp107-119.Thouless, R. H., "Experiments on Paranormal Guessing". British Journal of Psychology 33 (1942) pp15-27. secondly for his contribution to research into human
fertility Fertility is the capability to produce offspring through reproduction following the onset of sexual maturity. The fertility rate is the average number of children born by a female during her lifetime and is quantified demographically. Ferti ...
and the diagnosis of
pregnancy Pregnancy is the time during which one or more offspring develops ( gestates) inside a woman's uterus (womb). A multiple pregnancy involves more than one offspring, such as with twins. Pregnancy usually occurs by sexual intercourse, but ...
; and thirdly for being biological father to upwards of 600 offspring by anonymously donating
sperm Sperm is the male reproductive cell, or gamete, in anisogamous forms of sexual reproduction (forms in which there is a larger, female reproductive cell and a smaller, male one). Animals produce motile sperm with a tail known as a flagellum, ...
used by his wife the
obstetrician Obstetrics is the field of study concentrated on pregnancy, childbirth and the postpartum period. As a medical specialty, obstetrics is combined with gynecology under the discipline known as obstetrics and gynecology (OB/GYN), which is a surgic ...
Mary Barton to perform
artificial insemination Artificial insemination is the deliberate introduction of sperm into a female's cervix or uterine cavity for the purpose of achieving a pregnancy through in vivo fertilization by means other than sexual intercourse. It is a fertility treatment ...
on women at her private practice in the
Harley Street Harley Street is a street in Marylebone, Central London, which has, since the 19th century housed a large number of private specialists in medicine and surgery. It was named after Edward Harley, 2nd Earl of Oxford and Earl Mortimer.
area of London.Stevens, B., (Writer & Director) 'Bio-Dad' Documentary. Barna-Alper Productions. Canadian Broadcasting Corporation (CBC) 2009.


First marriage and early work in Austria

Wiesner was briefly married to the Austrian author, playwright, and scriptwriter
Anna Gmeyner Anna Wilhelmine Gmeyner (16 March 1902 – 3 January 1991) was an exiled German and Austrian writer, playwright and screenwriter, who is now best known for her novel '' Manja'' (1939). She also wrote under the names Anna Reiner, and Anna Morduch. ...
. They had one daughter: the author
Eva Ibbotson Eva Maria Charlotte Michelle Ibbotson (née Wiesner; born 21 January 1925 – 20 October 2010) was a British novelist born in Austria to a Jewish family who fled the Nazis. She is known for her children's literature. Some of her novels for adul ...
, born in 1925. The family moved to Scotland in 1926 when Wiesner accepted a post at the
University of Edinburgh The University of Edinburgh ( sco, University o Edinburgh, gd, Oilthigh Dhùn Èideann; abbreviated as ''Edin.'' in post-nominals) is a public research university based in Edinburgh, Scotland. Granted a royal charter by King James VI in 1 ...
. Wiesner and Gmeyner separated in 1928. He became a
naturalized citizen Naturalization (or naturalisation) is the legal act or process by which a non-citizen of a country may acquire citizenship or nationality of that country. It may be done automatically by a statute, i.e., without any effort on the part of the in ...
in 1934. During 1926 while Wiesner was still in Austria, he began investigating the role of
hormone A hormone (from the Greek participle , "setting in motion") is a class of signaling molecules in multicellular organisms that are sent to distant organs by complex biological processes to regulate physiology and behavior. Hormones are required ...
s in regulating
fertility Fertility is the capability to produce offspring through reproduction following the onset of sexual maturity. The fertility rate is the average number of children born by a female during her lifetime and is quantified demographically. Ferti ...
and their impact on fetal development. Wiesner also researched the possibility of preventing and terminating pregnancy by
physiological Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemica ...
means without mechanical intervention based on oral ingestion of manufactured substances containing hormones. He presented his first paper at the First
International Congress for Sex Research International is an adjective (also used as a noun) meaning "between nations". International may also refer to: Music Albums * ''International'' (Kevin Michael album), 2011 * ''International'' (New Order album), 2002 * ''International'' (The T ...
organized by the psychiatrist Albert Moll in Berlin. Two years later in 1927 the German gynecologists Bernhard Zondek and Selmar Ascheim discovered that the
urine Urine is a liquid by-product of metabolism in humans and in many other animals. Urine flows from the kidneys through the ureters to the urinary bladder. Urination results in urine being excreted from the body through the urethra. Cellul ...
of a pregnant woman contained a substance later identified as the
gonadotropic Gonadotropins are glycoprotein hormones secreted by gonadotropic cells of the anterior pituitary of vertebrates. This family includes the mammalian hormones follicle-stimulating hormone (FSH) and luteinizing hormone (LH), the placental/chorionic ...
hormone
human chorionic gonadotropin Human chorionic gonadotropin (hCG) is a hormone for the maternal recognition of pregnancy produced by trophoblast cells that are surrounding a growing embryo (syncytiotrophoblast initially), which eventually forms the placenta after implantatio ...
that caused an estrous reaction when injected into rats. This provided the basis for the
Aschheim-Zondek test The rabbit test, or Friedman test, was an early pregnancy test developed in 1931 by Maurice Friedman and Maxwell Edward Lapham at the University of Pennsylvania. Test The hormone human chorionic gonadotropin (hCG) is produced during pregnan ...
for pregnancy.


Early work in Scotland

The following year in 1928, Wiesner was appointed to the position of head of Sex Physiology by animal geneticist Francis Crew, Professor of Animal Genetics at the newly established Institute of Animal Genetics (IAG) established within the
University of Edinburgh The University of Edinburgh ( sco, University o Edinburgh, gd, Oilthigh Dhùn Èideann; abbreviated as ''Edin.'' in post-nominals) is a public research university based in Edinburgh, Scotland. Granted a royal charter by King James VI in 1 ...
. A number of notable scientists conducted research at the IAG, including physiologist
John Scott Haldane John Scott Haldane (; 2 May 1860 – 14/15 March 1936) was a British physician and physiologist famous for intrepid self-experimentation which led to many important discoveries about the human body and the nature of gases. He also experime ...
, zoologist Lancelot Hogben and evolutionary biologist
Julian Huxley Sir Julian Sorell Huxley (22 June 1887 – 14 February 1975) was an English evolutionary biologist, eugenicist, and internationalist. He was a proponent of natural selection, and a leading figure in the mid-twentieth century modern synthesis. ...
. It was there that Wiesner built upon the work of Zondek and
Aschheim Aschheim is a small town and municipality in the district of Munich in Bavaria in Germany. It lies beyond the northeastern outskirts of Munich. Aschheim is the location of BMW's test track opened by the manufacturer in 1972, and also has a golf ...
by examining the production and role of
hormone A hormone (from the Greek participle , "setting in motion") is a class of signaling molecules in multicellular organisms that are sent to distant organs by complex biological processes to regulate physiology and behavior. Hormones are required ...
s during
fertilization Fertilisation or fertilization (see spelling differences), also known as generative fertilisation, syngamy and impregnation, is the fusion of gametes to give rise to a new individual organism or offspring and initiate its development. Pro ...
and pregnancy. Zondek and Aschheim had thought that the hormone chorionic gonadotrophin was produced by the
pituitary gland In vertebrate anatomy, the pituitary gland, or hypophysis, is an endocrine gland, about the size of a chickpea and weighing, on average, in humans. It is a protrusion off the bottom of the hypothalamus at the base of the brain. The h ...
. But the research conducted at the IAG proved that it is secreted by the
placenta The placenta is a temporary embryonic and later fetal organ that begins developing from the blastocyst shortly after implantation. It plays critical roles in facilitating nutrient, gas and waste exchange between the physically separate mate ...
. In 1929, Wiesner visited Montreal, where he discussed with some scientists the possibility of using medicine derived from female hormones to delay menopause. Later, the scientists helped form the company Ayerst, McKenna and Harrison, Ltd (later,
Wyeth Wyeth, LLC was an American pharmaceutical company. The company was founded in Philadelphia, Pennsylvania, in 1860 as ''John Wyeth and Brother''. It was later known, in the early 1930s, as American Home Products, before being renamed to Wyeth in ...
) who marketed
Premarin Conjugated estrogens (CEs), or conjugated equine estrogens (CEEs), sold under the brand name Premarin among others, is an estrogen medication which is used in menopausal hormone therapy and for various other indications. It is a mixture of the ...
, a controversial
hormone replacement therapy Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. These symptoms can include hot flashes, vaginal ...
(HRT) drug based on pregnant mare's urine.


The Pregnancy Diagnosis Station

The work of Wiesner and
Crew A crew is a body or a class of people who work at a common activity, generally in a structured or hierarchical organization. A location in which a crew works is called a crewyard or a workyard. The word has nautical resonances: the tasks involved ...
led to the establishment of the Pregnancy Diagnosis Station at Edinburgh, which by 1939 was conducting ten thousand pregnancy tests per year, serving
physician A physician (American English), medical practitioner (Commonwealth English), medical doctor, or simply doctor, is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through th ...
s across the United Kingdom. In addition, Wiesner discovered that analysis of the
urine Urine is a liquid by-product of metabolism in humans and in many other animals. Urine flows from the kidneys through the ureters to the urinary bladder. Urination results in urine being excreted from the body through the urethra. Cellul ...
provided by
pregnant Pregnancy is the time during which one or more offspring develops ( gestates) inside a woman's uterus (womb). A multiple pregnancy involves more than one offspring, such as with twins. Pregnancy usually occurs by sexual intercourse, but ca ...
women could indicate the likelihood of
miscarriage Miscarriage, also known in medical terms as a spontaneous abortion and pregnancy loss, is the death of an embryo or fetus before it is able to survive independently. Miscarriage before 6 weeks of gestation is defined by ESHRE as biochemica ...
and abnormal fetal development.


Artificial insemination research

While at the Institute of Animal Genetics, Wiesner resumed his earlier research into the prevention of pregnancy which contributed to the formulation of a reliable
oral The word oral may refer to: Relating to the mouth * Relating to the mouth, the first portion of the alimentary canal that primarily receives food and liquid ** Oral administration of medicines ** Oral examination (also known as an oral exam or or ...
contraceptive Birth control, also known as contraception, anticonception, and fertility control, is the use of methods or devices to prevent unwanted pregnancy. Birth control has been used since ancient times, but effective and safe methods of birth contr ...
for women.Speirs, J., 'Secretly Connected: Anonymous Semen Donation, Genetics and Meaning of Kinship'. Doctoral Thesis. University of Edinburgh 2007. In addition, Wiesner collaborated with Kenneth Walker, a urological
surgeon In modern medicine, a surgeon is a medical professional who performs surgery. Although there are different traditions in different times and places, a modern surgeon usually is also a licensed physician or received the same medical training as ...
, at the
Royal Northern Hospital The Royal Northern Hospital was a general hospital on Holloway Road, London N7, near Tollington Way. It had inpatient, outpatient, accident and emergency facilities and was also a centre for postgraduate education. History The hospital was foun ...
where they had success in artificially inseminating women with sperm from anonymous donors in cases where the patient's husband was
infertile Infertility is the inability of a person, animal or plant to reproduce by natural means. It is usually not the natural state of a healthy adult, except notably among certain eusocial species (mostly haplodiploid insects). It is the normal st ...
or impotent. While working as an obstetrician at the
Royal Free Hospital The Royal Free Hospital (also known simply as the Royal Free) is a major teaching hospital in the Hampstead area of the London Borough of Camden. The hospital is part of the Royal Free London NHS Foundation Trust, which also runs services at Bar ...
in
London London is the capital and List of urban areas in the United Kingdom, largest city of England and the United Kingdom, with a population of just under 9 million. It stands on the River Thames in south-east England at the head of a estuary dow ...
during the early 1940s, Mary Barton had also had similar success and founded the first private clinic offering artificial insemination in the United Kingdom. In 1945, Barton collaborated with Wiesner and Walker on a paper for the ''
British Medical Journal ''The BMJ'' is a weekly peer-reviewed medical trade journal, published by the trade union the British Medical Association (BMA). ''The BMJ'' has editorial freedom from the BMA. It is one of the world's oldest general medical journals. Origi ...
'', describing their technique of human artificial insemination. The paper precipitated highly publicized condemnation from the
Pope The pope ( la, papa, from el, πάππας, translit=pappas, 'father'), also known as supreme pontiff ( or ), Roman pontiff () or sovereign pontiff, is the bishop of Rome (or historically the patriarch of Rome), head of the worldwide Cathol ...
who called it a sin, and the
Archbishop of Canterbury The archbishop of Canterbury is the senior bishop and a principal leader of the Church of England, the ceremonial head of the worldwide Anglican Communion and the diocesan bishop of the Diocese of Canterbury. The current archbishop is Just ...
who called for the British
parliament In modern politics, and history, a parliament is a legislative body of government. Generally, a modern parliament has three functions: representing the electorate, making laws, and overseeing the government via hearings and inquiries. Th ...
to make human artificial insemination illegal. Although it was not criminalized it was not legalized either and therefore the status of artificial insemination was ambiguous. Consequently, the activities of Barton and Wiesner at the fertility clinic were conducted in secrecy and all inseminated women were instructed to tell nobody about it.


Collaboration and marriage to Mary Barton

Subsequently, Barton and Wiesner jointly managed Barton's practice in London, during which time they married and had a son Jonathan Wiesner in 1945. (They also raised a daughter, Ruth.) From the beginning of Barton's practice until Wiesner's retirement in the mid-late 1960s, Mary Barton successfully inseminated an estimated 1500 women, the majority with sperm provided from Wiesner, some 1-200 from
neuroscientist A neuroscientist (or neurobiologist) is a scientist who has specialised knowledge in neuroscience, a branch of biology that deals with the physiology, biochemistry, psychology, anatomy and molecular biology of neurons, neural circuits, and glial ...
Derek Richter Derek Richter (14 January 1907 – 15 December 1995), English neuroscientist, was one of the founding fathers of the science of brain chemistry. Identifying monoamine oxidase and demonstrating its function in the brain early in his career, ...
as well as an unknown number from as yet unidentified donors. It is estimated that Wiesner is the biological
father A father is the male parent of a child. Besides the paternal bonds of a father to his children, the father may have a parental, legal, and social relationship with the child that carries with it certain rights and obligations. An adoptive fathe ...
of around 600 children born following these procedures, although some believe this figure could be as high as 1000.


Parapsychological research

In addition to his scientific research into
fertility Fertility is the capability to produce offspring through reproduction following the onset of sexual maturity. The fertility rate is the average number of children born by a female during her lifetime and is quantified demographically. Ferti ...
and pregnancy, Wiesner was intrigued by parapsychological phenomena, and in 1941, he met the
psychologist A psychologist is a professional who practices psychology and studies mental states, perceptual Perception () is the organization, identification, and interpretation of sensory information in order to represent and understand the pre ...
and parapsychologist
Robert Thouless Robert Henry Thouless (15 July 1894 – 25 September 1984) was an English psychologist and parapsychologist. He is best known as the author of '' Straight and Crooked Thinking'' (1930, 1953), which describes flaws in reasoning and argument. Ca ...
who was President of the
Society for Psychical Research The Society for Psychical Research (SPR) is a nonprofit organisation in the United Kingdom. Its stated purpose is to understand events and abilities commonly described as psychic or paranormal. It describes itself as the "first society to co ...
in
London London is the capital and List of urban areas in the United Kingdom, largest city of England and the United Kingdom, with a population of just under 9 million. It stands on the River Thames in south-east England at the head of a estuary dow ...
from 1942 until 1944. Together, Wiesner and Thouless collaborated on constructing a
hypothetical A hypothesis (plural hypotheses) is a proposed explanation for a phenomenon. For a hypothesis to be a scientific hypothesis, the scientific method requires that one can test it. Scientists generally base scientific hypotheses on previous obser ...
model to explain parapsychological phenomena. During this time, Wiesner coined the term 'Psi' to denote
extrasensory perception Extrasensory perception or ESP, also called sixth sense, is a claimed paranormal ability pertaining to reception of information not gained through the recognized physical senses, but sensed with the mind. The term was adopted by Duke Universit ...
and
psychokinesis Psychokinesis (from grc, ψυχή, , soul and grc, κίνησις, , movement, label=ㅤ), or telekinesis (from grc, τηλε, , far off and grc, κίνησις, , movement, label=ㅤ), is a hypothetical psychic ability allowing a person ...
. Their model, which was not intended to prove or disprove the existence of such phenomena, was first introduced in 1946, as part of a jointly authored paper where Wiesner and Robert Thouless use the term 'Psi' to indicate parapsychological phenomena.


Offspring

In 2007, the son of Weisner and Barton's marriage, Jonathan Weisner, provided
saliva Saliva (commonly referred to as spit) is an extracellular fluid produced and secreted by salivary glands in the mouth. In humans, saliva is around 99% water, plus electrolytes, mucus, white blood cells, epithelial cells (from which DNA can ...
and
blood Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood in the cir ...
from which his DNA was isolated and held on record. Since then, about fifty people have been able to verify that Bertold Paul Wiesner is their biological father through a DNA match to Jonathan Wiesner and to each other. Wiesner's biological offspring, conceived by artificial insemination performed by Mary Barton and confirmed by DNA testing, include author and
psychotherapist Psychotherapy (also psychological therapy, talk therapy, or talking therapy) is the use of psychological methods, particularly when based on regular personal interaction, to help a person change behavior, increase happiness, and overcome prob ...
Paul Newham Paul Newham (born 16 March 1962) is a retired British psychotherapist known for developing techniques used in psychology and psychotherapy to facilitate and examine two forms of human communication: the interpersonal communication through which p ...
,
barrister A barrister is a type of lawyer in common law jurisdictions. Barristers mostly specialise in courtroom advocacy and litigation. Their tasks include taking cases in superior courts and tribunals, drafting legal pleadings, researching law and givin ...
David Gollancz, writer
Michael Bywater Michael Bywater (born 11 May 1953) is an English non-fiction writer and broadcaster. He has worked for many London newspapers and periodicals and contributed to the design of computer games. Biography Bywater was educated at the independent Nottin ...
, comedian Simon Evans and
film maker Filmmaking (film production) is the process by which a motion picture is produced. Filmmaking involves a number of complex and discrete stages, starting with an initial story, idea, or commission. It then continues through screenwriting, castin ...
Barry Stevens, whose documentary films were instrumental in facilitating and publicizing the process by which Wiesner's offspring can confirm their paternity. In 2018, some of Wiesner's siblings were involved in a participatory action research process to explore their views about genomics research.


See also

*
Parapsychology Parapsychology is the study of alleged psychic phenomena ( extrasensory perception, telepathy, precognition, clairvoyance, psychokinesis (also called telekinesis), and psychometry) and other paranormal claims, for example, those related t ...
*
Anna Gmeyner Anna Wilhelmine Gmeyner (16 March 1902 – 3 January 1991) was an exiled German and Austrian writer, playwright and screenwriter, who is now best known for her novel '' Manja'' (1939). She also wrote under the names Anna Reiner, and Anna Morduch. ...
* List of people with the most children


References

{{DEFAULTSORT:Wiesner, Bertold P. 1901 births 1972 deaths Austrian physiologists Parapsychologists Sperm donors Austrian emigrants to Scotland Austrian Jews Scottish Jews