Berkeley bodies are

organelle In cell biology, an organelle is a specialized subunit, usually within a cell, that has a specific function. The name ''organelle'' comes from the idea that these structures are parts of cells, as organs are to the body, hence ''organelle,'' th ...

s unique to the yeast cell ''

Saccharomyces cerevisiae ''Saccharomyces cerevisiae'' () (brewer's yeast or baker's yeast) is a species of yeast (single-celled fungus microorganisms). The species has been instrumental in winemaking, baking, and brewing since ancient times. It is believed to have b ...

'', with a secretory mutation in the genes sec7 and sec14. The function of the organelle lies in the CTV (cytoplasm to vacuole targeting) pathway, which is a transport pathway for certain vacuolar hydrolases to be degenerated. The Berkeley body acts as the transport medium from the

cytoplasm In cell biology, the cytoplasm is all of the material within a eukaryotic cell, enclosed by the cell membrane, except for the cell nucleus. The material inside the nucleus and contained within the nuclear membrane is termed the nucleoplasm. ...

to the

vacuole A vacuole () is a membrane-bound organelle which is present in plant and fungal cells and some protist, animal, and bacterial cells. Vacuoles are essentially enclosed compartments which are filled with water containing inorganic and organic m ...

within this pathway. Studies have shown that Berkeley bodies share structural similarities with autophagosomes, which are involved in

autophagy Autophagy (or autophagocytosis; from the Ancient Greek , , meaning "self-devouring" and , , meaning "hollow") is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-dependent re ...

. The organelle consists of two enclosed membranes forming an enclosed lumen, which contains cytoplasm. It is formed by vesicles budding off the

Golgi apparatus The Golgi apparatus (), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells. Part of the endomembrane system in the cytoplasm, it packages proteins into membrane-bound vesicles i ...

or the

endoplasmic reticulum The endoplasmic reticulum (ER) is, in essence, the transportation system of the eukaryotic cell, and has many other important functions such as protein folding. It is a type of organelle made up of two subunits – rough endoplasmic reticulum ...

. They were discovered in 1980 by Peter Novick and

Randy Schekman Randy Wayne Schekman (born December 30, 1948) is an American cell biologist at the University of California, Berkeley, former editor-in-chief of ''Proceedings of the National Academy of Sciences'' and former editor of ''Annual Review of Cell and ...

, of the Department of Biochemistry,

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant un ...

.Peter Novick, Charles Field and Randy Schekman. Identification of 23 Complementation Groups Required for Post-translational Events in the Yeast Secretory Pathway. ''Cell'', Vol. 21, 205–215, August, 1980.

References

Organelles Saccharomyces cerevisiae {{Cell-biology-stub