The BRICHOS family consists of a variety of
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
s linked to major diseases, each containing a 100
amino acid
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha am ...
BRICHOS
domain
Domain may refer to:
Mathematics
*Domain of a function, the set of input values for which the (total) function is defined
**Domain of definition of a partial function
**Natural domain of a partial function
**Domain of holomorphy of a function
* Do ...
that is thought to have a
chaperone function.
These include
BRI2, which is related to familial British and Danish dementia (FBD and FDD);
Chondromodulin-I, related to
chondrosarcoma
Chondrosarcoma is a bone sarcoma, a primary cancer composed of cells derived from transformed cells that produce cartilage. A chondrosarcoma is a member of a category of tumors of bone and soft tissue known as sarcomas. About 30% of bone sarcomas ...
;
CA11
Carbonic anhydrase-related protein 11 is a protein that in humans is encoded by the ''CA11'' gene.
Function
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They pa ...
, related to
stomach cancer
Stomach cancer, also known as gastric cancer, is a cancer that develops from the lining of the stomach. Most cases of stomach cancers are gastric carcinomas, which can be divided into a number of subtypes, including gastric adenocarcinomas. Lymph ...
; and
surfactant protein C
Surfactant protein C (SP-C), is one of the Pulmonary surfactant#Proteins, pulmonary surfactant proteins. In humans this is encoded by the ''SFTPC'' gene.
It is a membrane protein.
Structure
SFTPC is a 197-residue protein made up of two halves ...
(SP-C), related to
respiratory distress syndrome (RDS).
Further reading
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References
{{DEFAULTSORT:Brichos Family
Protein domains
Protein families