BRCA1 C Terminus (BRCT) domain is a
family of evolutionarily related proteins. It is named after the C-terminal domain of
BRCA1
Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the ''BRCA1'' () gene. Orthologs are common in other vertebrate species, whereas invertebrate genomes may encode a more distantly related gene. ''BRCA1'' is a ...
, a DNA-repair protein that serves as a marker of breast cancer susceptibility.
The BRCT domain is found predominantly in proteins involved in
cell cycle checkpoint functions responsive to
DNA damage,
for example as found in the breast cancer DNA-repair protein
BRCA1
Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the ''BRCA1'' () gene. Orthologs are common in other vertebrate species, whereas invertebrate genomes may encode a more distantly related gene. ''BRCA1'' is a ...
. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain.
Examples
Human proteins containing this domain include:
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BARD1;
BRCA1
Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the ''BRCA1'' () gene. Orthologs are common in other vertebrate species, whereas invertebrate genomes may encode a more distantly related gene. ''BRCA1'' is a ...
*
CTDP1;
TDT or DNTT
*
ECT2
Protein ECT2 is a protein that in humans is encoded by the ''ECT2'' gene.
Function
The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of ...
*
LIG4
DNA ligase 4 is an enzyme that in humans is encoded by the LIG4 gene.
Function
The protein encoded by this gene is an ATP-dependent DNA ligase that joins double-strand breaks during the non-homologous end joining pathway of double-strand break ...
*
MCPH1;
MDC1
*
NBN
*
PARP1;
PARP4;
PAXIP1
PAX-interacting protein 1 is a protein that in humans is encoded by the ''PAXIP1'' gene.
Function
This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. ...
;
PES1
*
REV1;
RFC1;
TOPBP1;
TP53BP1;
XRCC1
References
External links
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Protein domains
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