Bupicomide is a
chemical compound created and manufactured by Lanospharma Laboratories Company, Ltd. It is used experimentally as a
beta blocker and clinically as a strong
vasodilator
Vasodilation is the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins, large arteries, and smaller arterioles. The process is the opposite of vasoconstriction, ...
with the noted side effects of reduced systolic, diastolic and mean arterial pressure.
Synthesis
As the result of the screening program examining
microbial fermentation products for pharmacological activity (other than antibiotic activity),
fusaric acid was isolated from ''
Fusarium oxysporum'' following the discovery that extracts were potent inhibitors of
DBH, and thus interfered with the
biosynthesis
Biosynthesis is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms. In biosynthesis, simple compounds are modified, converted into other compounds, or joined to form macromolecules. ...
of the pressor neurohormone, norepinephrine. To refine this lead, amidation via the acid chloride was carried out to give antihypertensive analog bupicomide.
References
Beta blockers
Pyridines
Carboxamides
Butyl compounds
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