Buphedrone, also known as α-methylamino-butyrophenone (MABP), is a
stimulant of the
phenethylamine and
cathinone chemical class Chemical classification systems attempt to classify elements or compounds according to certain chemical functional or structural properties. Whereas the structural properties are largely intrinsic, functional properties and the derived classificat ...
es that was first
synthesized in 1928. It is legal in most countries as a
research chemical, as long as it is not intended for human consumption.
Chemistry
Buphedrone is a beta-ketone and is related to the naturally occurring compounds,
cathinone and
cathine. It is also related to
methamphetamine, differing by the β-
ketone substituent (at the beta carbon) and an
ethyl group replacing the
methyl group at the carbon alpha to the
amine
In chemistry, amines (, ) are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (), wherein one or more hydrogen
Hydrogen is the chemical element wi ...
. One other name for buphedrone is phenylacetoethyl-methylamine.
Buphedrone as free base is very unstable; it is prone to dimerization like other α-amino ketones. Because of this, it is sold as various salts, with a
hydrochloride
In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine). An alternative name is chlorhydrate, which comes from French. An archaic alternative n ...
being most common.
Effects
Buphedrone increases spontaneous rodent
locomotor activity, potentiates the release of
dopamine from
dopaminergic nerve terminals in the
brain
A brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as vision. It is the most complex organ in a ve ...
, and causes
appetite suppression
An anorectic or anorexic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss. By contrast, an appetite stimulant is referred to as orexigenic.
The term is (from the Greek ''ἀν-'' (an-) = "without" and ...
. It also causes a possibly dangerous effect of decreasing subjective feeling of thirst. The effects of buphedrone have also been compared to
methamphetamine, with more euphoria and less physical stimulation. Most commonly reported effects include:
* Elevated mood,
euphoria
* Increased alertness
* Dilated
pupil
The pupil is a black hole located in the center of the Iris (anatomy), iris of the Human eye, eye that allows light to strike the retina.Cassin, B. and Solomon, S. (1990) ''Dictionary of Eye Terminology''. Gainesville, Florida: Triad Publishing ...
s (rare)
* Slurred speech (rare)
* Increased heart rate
* Talkativeness
* Increased empathy and sense of communication
* Increased sex drive
* Temporary erectile dysfunction in men
* Restlessness
* Insomnia
* Increased motivation
Depending on the route of administration, the duration varies from approximately 2.5 (IV) to 6 hours (orally) and may be followed by unpleasant symptoms associated with
withdrawal, which may include:
* Dysphoria
* Tiredness
* Sweating
* Loss of concentration
Legal status
As of October 2015 buphedrone is a controlled substance in China.
Buphedrone is an
Anlage II
Anlage may refer to:
* Allele, a specific version of a gene, as used by Gregor Mendel
* Anlage Süd
''Anlage Süd'' (English: ''Installation South'') was a pair of railway headquarters built for Adolf Hitler in the Nazi-occupied part of southe ...
controlled drug in Germany.
See also
*
Pentedrone
*
4-Methylbuphedrone
4-Methylbuphedrone (also known as 4-MeMABP, BZ-6378 and 4-Methyl-α-methylamino-butyrophenone), is a stimulant drug of the cathinone class that has been sold online as a designer drug.
It was first reported to the EMCDDA in November 2011.
Le ...
*
4-Methylpentedrone
4-Methylpentedrone (also known as 4-MPD and 4-Methyl-α-methylamino-valerophenone), is a stimulant drug of the cathinone class that has been sold online as a designer drug. It is a higher homolog of 4-methylmethcathinone (mephedrone) and 4-methy ...
References
{{Phenethylamines
Cathinones
Designer drugs
Norepinephrine-dopamine releasing agents