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Budipine (brand name Parkinsan) is an antiparkinson agent marketed for the treatment of
4-Phenyl-1-t-butyl-4-piperidinol, (1)
1-t-butyl-3-benzoyl-4-phenyl-4-piperidinol 1831-81-4(3)
Parkinson's disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms becom ...
.
While its exact mechanism of action is not well characterized, it is believed to be an NMDA receptor antagonist, but also promoting the synthesis of dopamine
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic compound, organic chemical of the catecholamine and phenethylamine families. Dopamine const ...
.
Because it provides additional benefits relative to existing treatments, it probably does not precisely mimic the mechanism of an existing known treatment.
Synthesis
4-Phenyl-1-t-butyl-4-piperidinol, (1)
1-t-butyl-3-benzoyl-4-phenyl-4-piperidinol 1831-81-4(3)See also
* AD-1211 *Delucemine
Delucemine (NPS-1506) is a drug which acts as an NMDA antagonist and a serotonin reuptake inhibitor, and has neuroprotective effects. It was originally investigated for the treatment of stroke and in 2004 was studied as a potential antidepressant ...
* Diphenidine
Diphenidine (1,2-DEP, DPD, DND) is a dissociative anesthetic that has been sold as a designer drug. The synthesis of diphenidine was first reported in 1924, and employed a Bruylants reaction analogous to the one that would later be used to discov ...
* Ephenidine
* Fluorolintane
* Lanicemine
* Methoxphenidine (MXP)
* MT-45
* Remacemide
References
Antiparkinsonian agents Drugs with unknown mechanisms of action 4-Phenylpiperidines Tert-butyl compounds Benzhydryl compounds {{nervous-system-drug-stub