Bruce H. Lipshutz (born 1951) is an American chemist. He is a professor at the

University of California, Santa Barbara The University of California, Santa Barbara (UC Santa Barbara or UCSB) is a Public university, public Land-grant university, land-grant research university in Santa Barbara County, California, Santa Barbara, California with 23,196 undergraduate ...

Biography

Lipshutz received his undergraduate degree in chemistry from

Binghamton University The State University of New York at Binghamton (Binghamton University or SUNY Binghamton) is a public university, public research university with campuses in Binghamton, New York, Binghamton, Vestal, New York, Vestal, and Johnson City, New Yor ...

in 1973. His graduate work was supervised by Harry H. Wasserman at

Yale Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the wor ...

. After a PhD degree in 1977, he spent two years at

Harvard Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le ...

as a post-doctoral researcher in the group of Nobel Laureate

E. J. Corey Elias James Corey (born July 12, 1928) is an American organic chemist. In 1990, he won the Nobel Prize in Chemistry "for his development of the theory and methodology of organic synthesis", specifically retrosynthetic analysis. Regarded by many a ...

. Soon after, he accepted a position of Assistant Professor at

UCSB The University of California, Santa Barbara (UC Santa Barbara or UCSB) is a public land-grant research university in Santa Barbara, California with 23,196 undergraduates and 2,983 graduate students enrolled in 2021–2022. It is part of the U ...

rising to the ranks of Professor in 1987. He has received the Alfred P. Sloan Foundation Fellowship and the Camille & Henry Dreyfus Teacher-Scholar Award. In 2011 he was awarded Presidential Green Chemistry Award. He is Co-founder of Zymes LLC.

Contributions

Reagents

*Aqueous Micellar Catalysis using TPGS-750-M and Nok. *Sustainable Palladium catalysis. * 2-(Trimethylsilyl)ethoxymethyl chloride: hydroxyl protecting group, selectively cleaved with fluoride ion under mild conditions.
Di-(4-chlorobenzyl)azodicarboxylate (DCAD)
recyclable and convenient alternative to diethyl azodicarboxylate (DEAD) or diisopropyl azodicarboxylate (DIAD) in

Mitsunobu reaction The Mitsunobu reaction is an organic reaction that converts an alcohol into a variety of functional groups, such as an ester, using triphenylphosphine and an azodicarboxylate such as diethyl azodicarboxylate (DEAD) or diisopropyl azodicarboxylat ...

. *Ligated copper hydride. *Heterogeneous catalysts: nickel-on-charcoal, copper-on-charcoal, nickel-in-graphite, copper+nickel-on-charcoal.

Methodologies

*Higher-order organocuprates (Lipshutz cuprates). *Chiral and achiral conjugate reductions. *Catalyst development for ppm Pd-catalyzed C-C couplings in water at ambient *Use of nonionic amphiphiles for transition metal-mediated cross coupling in organic synthesis. * Low-cost synthesis of

Coenzyme Q10 Coenzyme Q, also known as ubiquinone and marketed as CoQ10, is a coenzyme family that is ubiquitous in animals and most bacteria (hence the name ubiquinone). In humans, the most common form is coenzyme Q10 or ubiquinone-10. It is a 1,4-benzoq ...

References

{{DEFAULTSORT:Lipshutz, Bruce H. 1951 births Living people 21st-century American chemists Yale University alumni Harvard University staff University of California, Santa Barbara faculty Binghamton University alumni