Bromadiolone is a potent

anticoagulant Anticoagulants, commonly known as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time. Some of them occur naturally in blood-eating animals such as leeches and mosquitoes, where the ...

rodenticide. It is a second-generation

4-hydroxycoumarin 4-Hydroxycoumarin is a coumarin derivative with a hydroxy group at the 4-position. Occurrence 4-Hydroxycoumarin is an important fungal metabolite from the precursor coumarin, and its production leads to further fermentative production of the nat ...

derivative and vitamin K antagonist, often called a "super- warfarin" for its added potency and tendency to accumulate in the liver of the poisoned organism. When first introduced to the UK market in 1980, it was effective against rodent populations that had become resistant to first generation anticoagulants. The product may be used both indoors and outdoors for rats and mice. It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities.

Toxicity

Bromadiolone can be absorbed through the digestive tract, through the lungs, or through skin contact. The pesticide is generally given orally.Bromadiolone
The substance is a vitamin K antagonist. The lack of vitamin K in the circulatory system reduces blood clotting and will cause death due to

internal hemorrhaging Internal bleeding (also called internal hemorrhage) is a loss of blood from a blood vessel that collects inside the body. Internal bleeding is usually not visible from the outside. It is a serious medical emergency but the extent of severity depen ...

. Poisoning does not show effects for 24 to 36 hours after it is eaten and can take up to 2–5 days to cause death. Following are acute values for various animals (mammals): * rats 1.125 mg/kg b.w. * mice 1.75 mg/kg b.w. * rabbits 1 mg/kg b.w. * dogs > 10 mg/kg b.w. (oral

MTD MTD may refer to: Medicine * Maximum tolerated dose, in drug development * Muscle tension dysphonia, hyperfunctional musculature causing a hoarse voice Organizations * Makkal Tamil Desam Katchi (People's Tamil Land Party), a political party i ...

) * cats > 25 mg/kg b.w. (oral MTD)

Chemistry

The compound is used as a mixture of four stereoisomers. Its two stereoisomeric centers are at the phenyl- and the hydroxyl-substituted carbons in the carbon chain of the substituent at the 3 position of the coumarin.

Antidote

Vitamin K1 is used as antidote.

References

Anticoagulant rodenticides Organobromides Chromones Secondary alcohols 4-Hydroxycoumarins Biphenyls {{rodenticides

Toxicity

Chemistry

Antidote

See also

References