Brian R. Murphy is an American virologist and former co-chief of the Laboratory of Infectious Diseases at the National Institute of Allergy and Infectious Disease.

Education and career

Brian Murphy was born in 1942. He completed his undergraduate B.S. degree from Wesleyan University in 1964. He then went on to medical training, completing his M.D. in 1969 at the

University of Rochester Medical School The University of Rochester Medical Center (URMC), now known as UR Medicine, is located in Rochester, New York, is one of the main campuses of the University of Rochester and comprises the university's primary medical education, research and pat ...

, and internship the next year at

Stanford University Hospital Stanford University Medical Center is a medical complex which includes Stanford Health Care and Stanford Children's Health. It is consistently ranked as one of the best hospitals in the United States and serves as a teaching hospital for the S ...

. He moved to the National Institutes of Health in 1970 as a research associate in the Laboratory of Infectious Diseases within the National Institute of Allergy and Infectious Disease. In 1983, he was promoted to head the respiratory viruses section of the Laboratory of Infectious Diseases. In 2001, he became co-chief of the Laboratory of Infectious Diseases with

Robert H. Purcell Robert Harry Purcell (born 19 December 1935 in Iowa, United States) is an American virologist and former co-chief of the Laboratory of Infectious Diseases at the U.S. National Institute of Allergy and Infectious Disease. He is known for his work o ...

. He retired from the National Institutes of Health in 2010. Brian R Murphy 1984

Brian Murphy received the inaugural

Robert M. Chanock Robert Merritt Chanock (July 8, 1924 – July 30, 2010) was an American pediatrician and virologist who made major contributions to the prevention and treatment of childhood respiratory infections in more than 50 years spent at the National Insti ...

award for lifetime achievements in RSV research at the Respiratory Syncytial Virus 2003 symposium in November 2003. He served on the editorial board of the Journal of Virology.''Editorial Board''
Journal of Virology, 68 (1994), no. 8

Research

Murphy's research has focused on vaccine development for various viruses. In particular, his group is known for working on developing vaccines against respiratory syncytial virus,

parainfluenza virus Human parainfluenza viruses (HPIVs) are the viruses that cause human parainfluenza. HPIVs are a paraphyletic group of four distinct single-stranded RNA viruses belonging to the ''Paramyxoviridae'' family. These viruses are closely associated wit ...

, influenza virus,

dengue virus ''Dengue virus'' (DENV) is the cause of dengue fever. It is a mosquito-borne, single positive-stranded RNA virus of the family ''Flaviviridae''; genus ''Flavivirus''. Four serotypes of the virus have been found, a reported fifth has yet to be co ...

, and West Nile virus.

Notable publications

*Subbarao K, McAuliffe J... Murphy B (2004). Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice. ''Journal of Virology''. 78(7): pgs. 3572-3577 *Wright PF, Karron RA.. Murphy BR (2000). Evaluation of a live, cold-passaged, temperature-sensitive, respiratory syncytial virus vaccine candidate in infancy. ''Journal of Infectious Diseases''. 182(5): pgs. 1331-1342 *Collins PL, Hill MG... Murphy BR (1995). Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5' proximal open reading frame of the M2 mRNA in gene expression and provides a capability for vaccine development. ''Proceedings of the National Academy of Sciences''. 92(25): pgs. 11563-11567 *Subbarao EK, London W, Murphy BR (1993). A single amino acid in the PB2 gene of influenza A virus is a determinant of host range. ''Journal of Virology''. 67(4): pgs. 1761-1764 *Clements ML, Betts RF... Murphy BR (1986). Serum and nasal wash antibodies associated with resistance to experimental challenge with influenza A wild-type virus. ''Journal of Clinical Microbiology''. 24(1): pgs. 157-160

References

{{DEFAULTSORT:Murphy, Brian R. 1942 births American molecular biologists 20th-century American scientists Vaccinologists Wesleyan University alumni National Institutes of Health faculty University of Rochester alumni American virologists Living people