The ''Brachyspira'' holin (B-Hol) Family
TC# 1.E.55 consists of several proteins from the GTA holin of ''
Brachyspira
''Brachyspira'' is a genus of bacteria classified within the phylum Spirochaetota.See the List of Prokaryotic names with Standing in Nomenclature. Data extracted from
See the NCBIbr>webpage on SpirochaetesData extracted from
''Brachyspira sp ...
hyodysenteriae''
TC# 1.E.55.1.1, which facilitates gene transfer agent-release (see also
GTA holin family) to VSH-1 holin of ''
Brachyspira pilosicoli
''Brachyspira pilosicoli'' is a gram-negative, anaerobic, host-associated spirochete that colonizes the intestinal tract of animals and humans. It appears as a characteristic "false brush border" due to its end-on attachment to enterocytes of th ...
.'' VSH-1 is thought to participate in cell lysis. These proteins range in size from about 85 to 145 amino acyl residues (aas) and exhibit between 2 and 4 transmembrane segments (TMSs). A representative list of proteins belonging to the B-Hol family can be found in th
Transporter Classification Database
See also
*
Holin
*
Lysin
Lysins, also known as endolysins or murein hydrolases, are hydrolytic enzymes produced by bacteriophages in order to cleave the host's cell wall during the final stage of the lytic cycle. Lysins are highly evolved enzymes that are able to target ...
*
Transporter Classification Database
Further reading
* Matson, Eric G.; Thompson, M. Greg; Humphrey, Samuel B.; Zuerner, Richard L.; Stanton, Thad B. (2005-09-01)
"Identification of genes of VSH-1, a prophage-like gene transfer agent of Brachyspira hyodysenteriae" ''Journal of Bacteriology'' 187 (17): 5885–5892. . . . .
* Reddy, Bhaskara L.; Saier Jr., Milton H. (2013-11-01)
"Topological and phylogenetic analyses of bacterial holin families and superfamilies" ''Biochimica et Biophysica Acta (BBA) - Biomembranes'' 1828 (11): 2654–2671. . . .
* Saier, Milton H.; Reddy, Bhaskara L. (2015-01-01)
"Holins in Bacteria, Eukaryotes, and Archaea: Multifunctional Xenologues with Potential Biotechnological and Biomedical Applications" ''Journal of Bacteriology'' 197(1): 7–17. . . . .
* Wang, I. N.; Smith, D. L.; Young, R. (2000-01-01)
"Holins: the protein clocks of bacteriophage infections" ''Annual Review of Microbiology'' 54: 799–825. . . .
References
{{CCBYSASource, sourcepath=http://tcdb.org/search/result.php?tc=1.E.55, sourcearticle=1.E.55 The Brachyspira holin (B-Hol) Family, revision=699838558
Protein families
Membrane proteins
Transmembrane proteins
Transmembrane transporters
Transport proteins
Integral membrane proteins
Holins