Music
* ''Bottoms Up'' (Illinois Jacquet album), 1968 * ''Bottoms Up'' (Obie Trice album), 2012 *'' Bottoms Up!'', a 1959 album by jazz group The Three Sounds * "Bottoms Up" (Brantley Gilbert song), 2013 * "Bottoms Up" (Middle of the Road song), song by Scottish band Middle of the Road, 1972 * "Bottoms Up" (Nickelback song) from Nickelback's album ''Here and Now'' * "Bottoms Up" (Trey Songz song), 2010 *" U Was at the Club (Bottoms Up)", song by The BoyBoy West Coast *"Bottoms Up", a song by Keke Palmer from her debut album ''Film and television
* ''Bottoms Up'' (1934 film), a 1934 musical comedy film * ''Bottoms Up'' (1960 film), starring Jimmy Edwards * ''Bottoms Up'' (2006 film), a film starring Paris Hilton *Other uses
* Bottoms Up Club, a bar in Hong Kong * "Bottoms Up" Shot Cup, risqué ceramic cup featuring a naked girl draped over the bottomSee also
* Bottom-up (disambiguation) * Top-down (disambiguation) {{disambiguation