''Bothrops jararacussu'', commonly known in

English English usually refers to: * English language * English people English may also refer to: Peoples, culture, and language * ''English'', an adjective for something of, from, or related to England ** English national ide ...

as the jararacussu, is a highly venomous

pit viper The Crotalinae, commonly known as pit vipers,Mehrtens JM (1987). ''Living Snakes of the World in Color''. New York: Sterling Publishers. 480 pp. . crotaline snakes (from grc, κρόταλον ''krotalon'' castanet), or pit adders, are a subfa ...

species In biology, a species is the basic unit of classification and a taxonomic rank of an organism, as well as a unit of biodiversity. A species is often defined as the largest group of organisms in which any two individuals of the appropriate s ...

endemic Endemism is the state of a species being found in a single defined geographic location, such as an island, state, nation, country or other defined zone; organisms that are indigenous to a place are not endemic to it if they are also found elsew ...

South America South America is a continent entirely in the Western Hemisphere and mostly in the Southern Hemisphere, with a relatively small portion in the Northern Hemisphere at the northern tip of the continent. It can also be described as the southe ...

. It is one of the most dreaded snakes in South America and can grow up to .

Description and behavior

The jararacussu is a fairly large pit viper; growing up to 2.2 meters long, with a robust body and head and very aggressive behavior. The color of the body and head varies widely, the background color can be brown or yellow almost black, the pattern of dark and light scales are constituted in a series of dark arches, the spots form on the dorsal midline, which look like a letter ''x''. It has medium-sized eyes, with elliptical pupils vertically. With dorsal scales strongly keeled. They have large fangs with 2.5 cm, and can inject a lot of venom. They usually feed on amphibians and rodents. They are

ovoviviparous Ovoviviparity, ovovivipary, ovivipary, or aplacental viviparity is a term used as a "bridging" form of reproduction between egg-laying oviparous and live-bearing viviparous reproduction. Ovoviviparous animals possess embryos that develop insi ...

, giving birth to between 16 and 20 young, in the rainy season. Mainly diurnal and nocturnal, they usually warm up in the morning sun and venture forth to hunt at night.

Geographic range

It is found in

in coastal

Brazil Brazil ( pt, Brasil; ), officially the Federative Republic of Brazil (Portuguese: ), is the largest country in both South America and Latin America. At and with over 217 million people, Brazil is the world's fifth-largest country by area ...

(from

Bahia Bahia ( , , ; meaning "bay") is one of the 26 Federative units of Brazil, states of Brazil, located in the Northeast Region, Brazil, Northeast Region of the country. It is the fourth-largest Brazilian state by population (after São Paulo (sta ...

to Santa Catarina),

Paraguay Paraguay (; ), officially the Republic of Paraguay ( es, República del Paraguay, links=no; gn, Tavakuairetã Paraguái, links=si), is a landlocked country in South America. It is bordered by Argentina to the south and southwest, Brazil to th ...

, southeastern

Bolivia , image_flag = Bandera de Bolivia (Estado).svg , flag_alt = Horizontal tricolor (red, yellow, and green from top to bottom) with the coat of arms of Bolivia in the center , flag_alt2 = 7 × 7 square p ...

, and northeastern

Argentina Argentina (), officially the Argentine Republic ( es, link=no, República Argentina), is a country in the southern half of South America. Argentina covers an area of , making it the second-largest country in South America after Brazil, th ...

( Misiones Province). They can be found in the atlantic forest and semi-deciduous forest. They also live in perennial forests, pine forests in Paraná in low swampy regions and along river banks.

Common names

In Brazil, ''Bothrops jararacussu'' is known by many common names, among which are the following: ''jararacuçu, jararacuçu-verdadeiro, patrona, surucucu, surucucu-dourada, surucucu-tapete, urutu-dourado,'' and ''urutu-estrela''. Elsewhere in South America it is called Yarara-cussu, Yarara dorada, Yarara guasu, Yarara guazu, Painted Yope and Yoperojobobo.

Venom

Like all other species in the

genus Genus ( plural genera ) is a taxonomic rank used in the biological classification of extant taxon, living and fossil organisms as well as Virus classification#ICTV classification, viruses. In the hierarchy of biological classification, genus com ...

''Bothrops'', the jararacussu has rather potent venom, potent enough to kill sixteen people. The venom contains

cytotoxins Cytotoxicity is the quality of being toxic to cells. Examples of toxic agents are an immune cell or some types of venom, e.g. from the puff adder (''Bitis arietans'') or brown recluse spider (''Loxosceles reclusa''). Cell physiology Treating cells ...

hemotoxins Hemotoxins, haemotoxins or hematotoxins are toxins that destroy red blood cells, disrupt blood clotting, and/or cause organ degeneration and generalized tissue damage. The term ''hemotoxin'' is to some degree a misnomer since toxins that damage t ...

and myotoxins, one study with 29 bites of jararacussu in the state of

São Paulo São Paulo (, ; Portuguese for 'Saint Paul') is the most populous city in Brazil, and is the capital of the state of São Paulo, the most populous and wealthiest Brazilian state, located in the country's Southeast Region. Listed by the GaWC a ...

, Brazil. Severe signs of local and systemic envenoming such as

necrosis Necrosis () is a form of cell injury which results in the premature death of cells in living tissue by autolysis. Necrosis is caused by factors external to the cell or tissue, such as infection, or trauma which result in the unregulated dige ...

shock Shock may refer to: Common uses Collective noun *Shock, a historic commercial term for a group of 60, see English numerals#Special names * Stook, or shock of grain, stacked sheaves Healthcare * Shock (circulatory), circulatory medical emerge ...

, spontaneous systemic

hemorrhage Bleeding, hemorrhage, haemorrhage or blood loss, is blood escaping from the circulatory system from damaged blood vessels. Bleeding can occur internally, or externally either through a natural opening such as the mouth, nose, ear, urethra, vag ...

and

renal failure Kidney failure, also known as end-stage kidney disease, is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney failure is classified as eit ...

were observed in patients bitten by specimens over 50 cm. Smaller specimens were more likely to cause blood incoagulability. Fourteen patients developed

coagulopathy Coagulopathy (also called a bleeding disorder) is a condition in which the blood's ability to coagulate (form clots) is impaired. This condition can cause a tendency toward prolonged or excessive bleeding (bleeding diathesis), which may occur spo ...

, six had necrosis (causing amputation of one) and five had

abscess An abscess is a collection of pus that has built up within the tissue of the body. Signs and symptoms of abscesses include redness, pain, warmth, and swelling. The swelling may feel fluid-filled when pressed. The area of redness often extends b ...

. Two were in shock, while four developed kidney failure. Three patients aged 3, 11 and 65 years died due to respiratory and

circulatory The blood circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the entire body of a human or other vertebrate. It includes the cardiovascular system, or vascular system, tha ...

failure, even with large doses of specific anti-venom management in an intensive care unit. The autopsy of two patients showed

acute tubular necrosis Acute tubular necrosis (ATN) is a medical condition involving the death of tubular epithelial cells that form the renal tubules of the kidneys. Because necrosis is often not present, the term acute tubular injury (ATI) is preferred by pathologists ...

, cerebral edema, hemorrhagic rhabdomyolysis at the site of the bite and

disseminated intravascular coagulation Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the body, blocking small blood vessels. Symptoms may include chest pain, shortness of breath, leg pain, problems speaking, or problems moving parts o ...

. One survivor had chronic renal failure, whose autopsy showed bilateral cortical necrosis.

Cerebral hemorrhage Intracerebral hemorrhage (ICH), also known as cerebral bleed, intraparenchymal bleed, and hemorrhagic stroke, or haemorrhagic stroke, is a sudden bleeding into the tissues of the brain, into its ventricles, or into both. It is one kind of bleed ...

and kidney failure have already been reported, in a man bitten by a young jararacussu. The LD₅₀ value is 0.14 mg/kg (intravenous injection), 4.92 mg/kg (subcutaneous injection) and 2.73 mg/kg (intraperitoneal injection), while the venom yield is 1000 mg, enough to kill 10,163 rats. Two myotoxins with PLA2 structure, BthTX-I and BthTX-II were isolated from the venom of B. jararacussu, BthTX-I induces various effects such as edema, degranulation of

mast cells A mast cell (also known as a mastocyte or a labrocyte) is a resident cell of connective tissue that contains many granules rich in histamine and heparin. Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a par ...

, irreversible blocking of

muscle contraction Muscle contraction is the activation of tension-generating sites within muscle cells. In physiology, muscle contraction does not necessarily mean muscle shortening because muscle tension can be produced without changes in muscle length, such as ...

, rupture of

liposomes A liposome is a small artificial Vesicle (biology and chemistry), vesicle, spherical in shape, having at least one lipid bilayer. Due to their hydrophobicity and/or hydrophilicity, biocompatibility, particle size and many other properties, lipo ...

, and

cytotoxicity Cytotoxicity is the quality of being toxic to cells. Examples of toxic agents are an immune cell or some types of venom, e.g. from the puff adder (''Bitis arietans'') or brown recluse spider (''Loxosceles reclusa''). Cell physiology Treating cells ...

on muscle cells and

endothelial The endothelium is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. The endothelium forms an interface between circulating blood or lymph in the lumen and the rest of the vessel ...

, while BthTX-II induces edema and

leukocyte White blood cells, also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. All white blood cells are produced and derived from mult ...

migration.

References

External links