The bombesin receptor subtype 3 also known as BRS-3 or BB
3 is a
protein which in humans is encoded by the ''BRS3''
gene.
Function
Mammalian
bombesin-like peptides are widely distributed in the
central nervous system as well as in the
gastrointestinal tract
The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organ (biology), organs of the digestive syste ...
, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include
gastrin-releasing peptide receptor
The gastrin-releasing peptide receptor (GRPR), now properly known as BB2 is a G protein-coupled receptor whose endogenous ligand is gastrin releasing peptide. In humans it is highly expressed in the pancreas and is also expressed in the stoma ...
,
neuromedin B receptor
The neuromedin B receptor (NMBR), now known as BB1 is a G protein-coupled receptor whose endogenous ligand is neuromedin B. In humans, this protein is encoded by the ''NMBR'' gene.
Neuromedin B receptor binds neuromedin B, a potent mitogen and ...
, and bombesin-like receptor-3 (BRS3; this article).
BB
3 is a
G protein-coupled receptor.
BB
3 only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an
orphan receptor.
References
Further reading
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External links
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G protein-coupled receptors
{{transmembranereceptor-stub