Birdsey Renshaw
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Birdsey Renshaw (October 10, 1911, Middletown, Connecticut – November 23, 1948,
Portland, Oregon Portland (, ) is a port city in the Pacific Northwest and the largest city in the U.S. state of Oregon. Situated at the confluence of the Willamette and Columbia rivers, Portland is the county seat of Multnomah County, the most populous co ...
) was an American electrophysiologist and neuroscientist. He is known for his 1941 discovery of the eponymous
Renshaw cell Renshaw cells are inhibitory interneurons found in the gray matter of the spinal cord, and are associated in two ways with an alpha motor neuron. * They receive an excitatory collateral from the alpha neuron's axon as they emerge from the motor ...
s and the Renshaw inhibition (recurrent inhibition), which is a negative feedback mechanism associated with the Renshaw cell action.


Biography

In 1936 he graduated with an M.D. from
Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...
and then joined Alexander Forbes's neurophysiological research team in Harvard Medical School's physiology department. There he learned how to record cerebral action potentials using
amplifier An amplifier, electronic amplifier or (informally) amp is an electronic device that can increase the magnitude of a signal (a time-varying voltage or current). It may increase the power significantly, or its main effect may be to boost t ...
s and cathode-ray tubes. He developed microelectrodes from ultra-clean Pyrex pipettes and applied the microelectrodes to make extracellular recordings of action potentials found in the mammalian hippocampus and cortex. In 1938 he received his Ph.D. with thesis ''The Electrical Potentials Recorded in the Brain with Microelectrodes''. In 1938, after receiving his Ph.D.. he joined Herbert Spencer Gasser's group at the Rockefeller Institute for Medical Research (now named Rockefeller University). The research group included David Lloyd (1911–1985),
Rafael Lorente de Nó Rafael Lorente de Nó (April 8, 1902 – April 2, 1990) was a Spanish neuroscientist who advanced the scientific understanding of the nervous system with his seminal research. He was a member of the National Academy of Sciences. The National Acad ...
, and Harry Grundfest. In 1948 Renshaw died of
polio Poliomyelitis, commonly shortened to polio, is an infectious disease caused by the poliovirus. Approximately 70% of cases are asymptomatic; mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe s ...
within three days of the onset of symptoms. In 1954 Eccles, Fatt, and Koketsu used intracellular recording to confirm Renshaw's findings and introduced the term "Renshaw cell".


Family

Birdsey Renshaw's mother was Laura Birdsey Renshaw (1878–1930) and his father was Raemer Rex Renshaw (1880–1938), a professor of organic chemistry at New York University and, during WW I, a U.S. Army captain in the Chemical Warfare Service. Late on the night of September 23, 1938, Professor Raemer Rex Renshaw and his second wife died after falling nineteen stories from their
Tudor City Tudor City is an apartment complex located on the southern edge of Turtle Bay on the East Side of Manhattan in New York City, near Turtle Bay's border with Murray Hill. It lies on a low cliff, which is east of Second Avenue between 40th and ...
apartment at 45
Prospect Place Prospect Place, also known as Trinway Mansion and Prospect Place Mansion, is a 29-room mansion built by abolitionist George Willison Adams (G. W. Adams) in Trinway, Ohio, just north of Dresden in 1856. Today, it is the home of the non-profit ...
in Manhattan. In August 1939 in Holyoke, Massachusetts, Birdsey Renshaw married Janet Card Hayes, who graduated from Mount Holyoke College. She had two brothers and two sisters. The younger of her two brothers was Samuel Perkins Hayes Jr. (1910–2002), who was a social psychologist, a consultant to the
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from 1961 to 1969, and president of the
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until 1975. Birdsey and Janet Renshaw had two sons, Thomas Hayes Renshaw and Bruce Birdsey Renshaw.


Selected publications

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References


External links

* {{DEFAULTSORT:Renshaw, Birdsey 1911 births 1948 deaths American neuroscientists American physiologists Electrophysiologists Neurophysiologists Harvard Medical School alumni Rockefeller University people People from Middletown, Connecticut