Biotin-carboxyl-carrier Protein

Biotin Carboxyl Carrier Protein (BCCP) refers to proteins containing a

biotin attachment domain Biotin/lipoyl attachment domain has a conserved lysine residue that binds biotin or lipoic acid. Biotin plays a catalytic role in some carboxyl transfer reactions and is covalently attached, via an amide bond, to a lysine residue in enzymes requi ...

that carry

biotin Biotin (or vitamin B7) is one of the B vitamins. It is involved in a wide range of metabolic processes, both in humans and in other organisms, primarily related to the utilization of fats, carbohydrates, and amino acids. The name ''biotin'', bor ...

and carboxybiotin throughout the

ATP ATP may refer to: Companies and organizations * Association of Tennis Professionals, men's professional tennis governing body * American Technical Publishers, employee-owned publishing company * ', a Danish pension * Armenia Tree Project, non ...

-dependent carboxylation by biotin-dependent carboxylases. In the case of ''

E. coli ''Escherichia coli'' (),Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. also known as ''E. coli'' (), is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus ''Escher ...

Acetyl-CoA carboxylase Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme () that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). ACC is ...

, the BCCP is a separate protein known as ''accB'' (). On the other hand, in ''

Haloferax mediterranei ''Haloferax mediterranei'' is a species of archaea in the family Haloferacaceae. Discovery ''Haloferax mediterranei'' was discovered in 1983 in marine salterns in the village of Santa Pola, Spain. The species was initially named ''Halobacterium ...

'' Propionyl-CoA carboxylase, the BCCP ''pccA'' () is fused with

biotin carboxylase In enzymology, a biotin carboxylase () is an enzyme that catalyzes the chemical reaction : ATP + biotin-carboxyl-carrier protein + CO2 \rightleftharpoons ADP + phosphate + carboxybiotin-carboxyl-carrier protein The three substrates of this e ...

. Coenzymes Enzymes Metabolism Proteins {{Protein-stub