Bioproduction is the production of biologics-based therapeutic drugs including protein-based therapeutics,

vaccines A vaccine is a biological preparation that provides active acquired immunity The adaptive immune system, also known as the acquired immune system, is a subsystem of the immune system that is composed of specialized, systemic cells and pro ...

, gene therapies as well as cell therapies; drugs so complex they can only be made in living systems or indeed are a living system (cell therapies). In practice, ‘bioproduction’ has become loosely synonymous with ‘

bioprocessing Bioprocess engineering, also biochemical engineering, is a specialization of chemical engineering or biological engineering. It deals with the design and development of equipment and processes for the manufacturing of products such as agriculture, ...

’ as a way to describe the manufacturing process using,

cell culture Cell culture or tissue culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment. The term "tissue culture" was coined by American pathologist Montrose Thomas Burrows. This te ...

chromatography In chemical analysis, chromatography is a laboratory technique for the separation of a mixture into its components. The mixture is dissolved in a fluid solvent (gas or liquid) called the ''mobile phase'', which carries it through a system (a ...

, formulation and related analytical testing for large molecule drugs,

and cellular therapies. Many combinations of reactor types and culture modes are now available for use in bioproduction: e.g.,

pharming Pharming is a cyberattack intended to redirect a website's traffic to another, fake site by installing a malicious program on the computer. Pharming can be conducted either by changing the hosts file on a victim's computer or by exploitation of a ...

, rocking wave-agitated bag batch, stirred-tank or air-lift

fed-batch Fed-batch culture is, in the broadest sense, defined as an operational technique in biotechnological processes where one or more nutrients (substrates) are fed (supplied) to the bioreactor during cultivation and in which the product(s) remain in ...

, and hollow-fiber or spin-filter perfusion. No single production format is inherently superior; that determination depends on many manufacturing capabilities, requirements, and goals.Whitford, William G., {{cite web , url=http://www.iclickmedia.com/bioprocessors/4_4_Whitford.pdf , title=Archived copy , accessdate=2012-02-17 , url-status=dead, archiveurl=https://web.archive.org/web/20111124224955/http://www.iclickmedia.com/bioprocessors/4_4_Whitford.pdf , archivedate=2011-11-24 , ''Feb-Batch Mammalian Cell Culture in Bioproduction'', April 2006 New cell lines, concerns about product quality and safety, emerging

biosimilars A biosimilar (also known as follow-on biologic or subsequent entry biologic) is a biologic medical product that is almost an identical copy of an original product that is manufactured by a different company. Biosimilars are officially approved v ...

, worldwide demand for

, and cellular medicine drive new innovative solutions in bioproduction.

References

Biopharmaceuticals

See also

References