Bion 9
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OR:

Kosmos 2044, or Bion 9 (in
Russian Russian(s) refers to anything related to Russia, including: *Russians (, ''russkiye''), an ethnic group of the East Slavic peoples, primarily living in Russia and neighboring countries *Rossiyane (), Russian language term for all citizens and peo ...
: ''Бион 9'', ''Космос 2044'') was a
biomedical research Medical research (or biomedical research), also known as experimental medicine, encompasses a wide array of research, extending from "basic research" (also called ''bench science'' or ''bench research''), – involving fundamental scientif ...
mission involving in nine countries plus ESA: United Kingdom,
Hungarian People's Republic The Hungarian People's Republic ( hu, Magyar Népköztársaság) was a one-party socialist state from 20 August 1949 to 23 October 1989. It was governed by the Hungarian Socialist Workers' Party, which was under the influence of the Soviet Uni ...
,
East Germany East Germany, officially the German Democratic Republic (GDR; german: Deutsche Demokratische Republik, , DDR, ), was a country that existed from its creation on 7 October 1949 until its dissolution on 3 October 1990. In these years the state ...
,
Polish People's Republic The Polish People's Republic ( pl, Polska Rzeczpospolita Ludowa, PRL) was a country in Central Europe that existed from 1947 to 1989 as the predecessor of the modern Republic of Poland. With a population of approximately 37.9 million nea ...
,
Czechoslovakia , rue, Чеськословеньско, , yi, טשעכאסלאוואקיי, , common_name = Czechoslovakia , life_span = 1918–19391945–1992 , p1 = Austria-Hungary , image_p1 ...
, United States, Canada, Australia,
Soviet Union The Soviet Union,. officially the Union of Soviet Socialist Republics. (USSR),. was a transcontinental country that spanned much of Eurasia from 1922 to 1991. A flagship communist state, it was nominally a federal union of fifteen national ...
and
European Space Agency , owners = , headquarters = Paris, Île-de-France, France , coordinates = , spaceport = Guiana Space Centre , seal = File:ESA emblem seal.png , seal_size = 130px , image = Views in the Main Control Room (1205 ...
(ESA). It was part of the
Bion program The Bion satellites (russian: Бион), also named Biocosmos, is a series of Soviet (later Russian) biosatellites focused on space medicine. Bion space program Bion precursor flights and Bion flights The Soviet biosatellite program bega ...
.


Mission

Eighty experiments were conducted in such categories as
motion sickness Motion sickness occurs due to a difference between actual and expected motion. Symptoms commonly include nausea, vomiting, cold sweat, headache, dizziness, tiredness, loss of appetite, and increased salivation. Complications may rarely include d ...
,
reproduction Reproduction (or procreation or breeding) is the biological process by which new individual organisms – "offspring" – are produced from their "parent" or parents. Reproduction is a fundamental feature of all known life; each individual or ...
and
regeneration Regeneration may refer to: Science and technology * Regeneration (biology), the ability to recreate lost or damaged cells, tissues, organs and limbs * Regeneration (ecology), the ability of ecosystems to regenerate biomass, using photosynthesis ...
,
immunology Immunology is a branch of medicineImmunology for Medical Students, Roderick Nairn, Matthew Helbert, Mosby, 2007 and biology that covers the medical study of immune systems in humans, animals, plants and sapient species. In such we can see there ...
, and readaptation to a normal gravity environment. A number of different biological specimens were used, including
rodent Rodents (from Latin , 'to gnaw') are mammals of the order Rodentia (), which are characterized by a single pair of continuously growing incisors in each of the upper and lower jaws. About 40% of all mammal species are rodents. They are na ...
s. The joint United States/
Soviet Union The Soviet Union,. officially the Union of Soviet Socialist Republics. (USSR),. was a transcontinental country that spanned much of Eurasia from 1922 to 1991. A flagship communist state, it was nominally a federal union of fifteen national ...
experiments were conducted on 2
rhesus monkey The rhesus macaque (''Macaca mulatta''), colloquially rhesus monkey, is a species of Old World monkey. There are between six and nine recognised subspecies that are split between two groups, the Chinese-derived and the Indian-derived. Generally b ...
s and 10 male
Wistar rat A laboratory rat or lab rat is a brown rat of the subspecies '' Rattus norvegicus domestica'' which is bred and kept for scientific research. While less commonly used for research than mice (see laboratory mouse), rats have served as an importa ...
s. The biological payload also included cell cultures (''
Escherichia coli ''Escherichia coli'' (),Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. also known as ''E. coli'' (), is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus ''Escher ...
''). The prime occupants were two
macaque monkey The macaques () constitute a genus (''Macaca'') of gregarious Old World monkeys of the subfamily Cercopithecinae. The 23 species of macaques inhabit ranges throughout Asia, North Africa, and (in one instance) Gibraltar. Macaques are principally ...
s. The 2.3 m diameter descent sphere was successfully recovered after 14 days, but a failure in the thermal control system resulted in the deaths of some of the specimens.


Scientific experiments

The Bion 9 mission was composed of 80 scientific experiments, but only 30 experiments returned: * Bone Biochemistry and Mineral Distribution in the Femurs of Rats: Determine the biochemical nature of the mineralization defects in the femurs of young rats after spaceflight. The institutions participating in this experiment were
NASA Ames Research Center The Ames Research Center (ARC), also known as NASA Ames, is a major NASA research center at Moffett Federal Airfield in California's Silicon Valley. It was founded in 1939 as the second National Advisory Committee for Aeronautics (NACA) laborat ...
,
University of North Carolina The University of North Carolina is the multi-campus public university system for the state of North Carolina. Overseeing the state's 16 public universities and the NC School of Science and Mathematics, it is commonly referred to as the UNC Sy ...
,
University of Connecticut The University of Connecticut (UConn) is a public land-grant research university in Storrs, Connecticut, a village in the town of Mansfield. The primary 4,400-acre (17.8 km2) campus is in Storrs, approximately a half hour's drive from Hart ...
,
University of California, Santa Cruz The University of California, Santa Cruz (UC Santa Cruz or UCSC) is a public university, public Land-grant university, land-grant research university in Santa Cruz, California. It is one of the ten campuses in the University of California syste ...
,
University College In a number of countries, a university college is a college institution that provides tertiary education but does not have full or independent university status. A university college is often part of a larger university. The precise usage varies ...
in
London London is the capital and largest city of England and the United Kingdom, with a population of just under 9 million. It stands on the River Thames in south-east England at the head of a estuary down to the North Sea, and has been a majo ...
and Institute for Medical and Biological Problems (IMBP) in
Moscow Moscow ( , US chiefly ; rus, links=no, Москва, r=Moskva, p=mɐskˈva, a=Москва.ogg) is the capital and largest city of Russia. The city stands on the Moskva River in Central Russia, with a population estimated at 13.0 million ...
). * Biomechanical and Morphological Alteration of Intramuscular Connective Tissues: The objective of this experiment was to characterize the structural and material properties of cortical and trabecular bone samples, tendons and intervertebral disks; and to correlate the biomechanical properties of these tissues to the type and quality of structural
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
s. The institutions participating in this experiment were
University of Iowa The University of Iowa (UI, U of I, UIowa, or simply Iowa) is a public university, public research university in Iowa City, Iowa, United States. Founded in 1847, it is the oldest and largest university in the state. The University of Iowa is org ...
,
West Virginia University West Virginia University (WVU) is a public land-grant research university with its main campus in Morgantown, West Virginia. Its other campuses are those of the West Virginia University Institute of Technology in Beckley, Potomac State College ...
,
University of Wisconsin-Madison A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, the ...
and Institute for Medical and Biological Problems (IMBP). * Gravity and Skeletal Growth: The objective of this experiment was to study
bone cells An osteocyte, an oblate shaped type of bone cell with dendritic processes, is the most commonly found cell in mature bone. It can live as long as the organism itself. The adult human body has about 42 billion of them. Osteocytes do not divide and ...
, bone matrix and mineral characteristics, bone cell kinetics, and bone
blood Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood in the c ...
supply. The institutions participating in this experiment were
NASA Ames Research Center The Ames Research Center (ARC), also known as NASA Ames, is a major NASA research center at Moffett Federal Airfield in California's Silicon Valley. It was founded in 1939 as the second National Advisory Committee for Aeronautics (NACA) laborat ...
,
Indiana University Indiana University (IU) is a system of public universities in the U.S. state of Indiana. Campuses Indiana University has two core campuses, five regional campuses, and two regional centers under the administration of IUPUI. *Indiana Universit ...
,
Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...
,
Saint Louis University Saint Louis University (SLU) is a private Jesuit research university with campuses in St. Louis, Missouri, United States, and Madrid, Spain. Founded in 1818 by Louis William Valentine DuBourg, it is the oldest university west of the Mississip ...
and Institute for Medical and Biological Problems (IMBP). * Mineral Distribution and Balance in Rats during Space Flight: The objective of this experiment was to determine the abundance and distribution of mineral components and protein (
osteocalcin Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid) noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein. Because osteocalcin has gl ...
) within a vertebra; and to determine absorption and excretion of
manganese Manganese is a chemical element with the symbol Mn and atomic number 25. It is a hard, brittle, silvery metal, often found in minerals in combination with iron. Manganese is a transition metal with a multifaceted array of industrial alloy use ...
,
magnesium Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a shiny gray metal having a low density, low melting point and high chemical reactivity. Like the other alkaline earth metals (group 2 of the periodic ta ...
and
zinc Zinc is a chemical element with the symbol Zn and atomic number 30. Zinc is a slightly brittle metal at room temperature and has a shiny-greyish appearance when oxidation is removed. It is the first element in group 12 (IIB) of the periodi ...
and their relationship to
calcium Calcium is a chemical element with the symbol Ca and atomic number 20. As an alkaline earth metal, calcium is a reactive metal that forms a dark oxide-nitride layer when exposed to air. Its physical and chemical properties are most similar to ...
balance and bone
osteocalcin Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid) noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein. Because osteocalcin has gl ...
. The institutions participating in this experiment were
University of California, San Francisco The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California. It is part of the University of California system and is dedicated entirely to health science and life science. It cond ...
and Institute for Medical and Biological Problems (IMBP). * Morphometric and EM Analyses of Tibial Epiphyseal Plates: The objective of this experiment was to measure the growth plate of the tibia as an index of its longitudinal growth, and to study the ultrastructure and chemical composition of the growth plate. The institutions participating in this experiment were
University of Texas Medical Branch The University of Texas Medical Branch (UTMB) is a public academic health science center in Galveston, Texas. It is part of the University of Texas System. UTMB includes the oldest medical school in Texas, and has about 11,000 employees. In Febr ...
and Institute for Medical and Biological Problems (IMBP). * Metabolic and Morphologic Properties of Muscle Fibers and Motor Neurons: The objective of this experiment was to study
microgravity The term micro-g environment (also μg, often referred to by the term microgravity) is more or less synonymous with the terms ''weightlessness'' and ''zero-g'', but emphasising that g-forces are never exactly zero—just very small (on the I ...
related muscular atrophy effects in various types of muscle and in spinal motor
neuron A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa. N ...
s, with emphasis on the metabolic changes. The institutions participating in this experiment were
University of California, Los Angeles The University of California, Los Angeles (UCLA) is a public land-grant research university in Los Angeles, California. UCLA's academic roots were established in 1881 as a teachers college then known as the southern branch of the California St ...
,
University of Alberta The University of Alberta, also known as U of A or UAlberta, is a public research university located in Edmonton, Alberta, Canada. It was founded in 1908 by Alexander Cameron Rutherford,"A Gentleman of Strathcona – Alexander Cameron Rutherfor ...
in the Canada,
University of Kansas The University of Kansas (KU) is a public research university with its main campus in Lawrence, Kansas, United States, and several satellite campuses, research and educational centers, medical centers, and classes across the state of Kansas. Tw ...
,
University of Wisconsin–Madison A university () is an educational institution, institution of higher education, higher (or Tertiary education, tertiary) education and research which awards academic degrees in several Discipline (academia), academic disciplines. Universities ty ...
and Institute for Medical and Biological Problems (IMBP). * Skeletal Muscle Atrophy: The objective of this experiment was to determine the morphological and biochemical responses of various types of muscles to
microgravity The term micro-g environment (also μg, often referred to by the term microgravity) is more or less synonymous with the terms ''weightlessness'' and ''zero-g'', but emphasising that g-forces are never exactly zero—just very small (on the I ...
. The institutions participating in this experiment were the
University of Louisville The University of Louisville (UofL) is a public research university in Louisville, Kentucky. It is part of the Kentucky state university system. When founded in 1798, it was the first city-owned public university in the United States and one of ...
in the
Kentucky Kentucky ( , ), officially the Commonwealth of Kentucky, is a state in the Southeastern region of the United States and one of the states of the Upper South. It borders Illinois, Indiana, and Ohio to the north; West Virginia and Virginia to ...
and Institute for Medical and Biological Problems (IMBP). * Investigation of Microgrovity Induced Nerve and Muscle Breakdown: This experiment was a morphological, histochemical, immunocytochemical, and
biochemical Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology an ...
investigation of microgravity induced nerve and muscle breakdown. Its main objective was to study, by light and
electron The electron ( or ) is a subatomic particle with a negative one elementary electric charge. Electrons belong to the first generation of the lepton particle family, and are generally thought to be elementary particles because they have no kn ...
microscopy Microscopy is the technical field of using microscopes to view objects and areas of objects that cannot be seen with the naked eye (objects that are not within the resolution range of the normal eye). There are three well-known branches of micr ...
, the long term effects of
microgravity The term micro-g environment (also μg, often referred to by the term microgravity) is more or less synonymous with the terms ''weightlessness'' and ''zero-g'', but emphasising that g-forces are never exactly zero—just very small (on the I ...
and early readaptation to
gravity In physics, gravity () is a fundamental interaction which causes mutual attraction between all things with mass or energy. Gravity is, by far, the weakest of the four fundamental interactions, approximately 1038 times weaker than the stro ...
on the structure of nerve and skeletal muscles; and to study the biochemistry of muscle protein breakdown. The institutions participating in this experiment were
San Jose State University San José State University (San Jose State or SJSU) is a public university in San Jose, California. Established in 1857, SJSU is the oldest public university on the West Coast and the founding campus of the California State University (CSU) sys ...
,
Medical College of Wisconsin The Medical College of Wisconsin (MCW) is a private medical school, pharmacy school, and graduate school of sciences headquartered in Milwaukee, Wisconsin. The school was established in 1893 and is the largest research center in eastern Wisconsin ...
, Institute for Medical and Biological Problems (IMBP) and
University of Sydney The University of Sydney (USYD), also known as Sydney University, or informally Sydney Uni, is a public research university located in Sydney, Australia. Founded in 1850, it is the oldest university in Australia and is one of the country's si ...
, Australia. * Myosin Isoform Expression in Rodent Skeletal Muscle: The objective of this experiment was to study the effect of microgravity and contractile protein expression in antigravity and non-antigravity rodent skeletal muscle. The institutions participating in this experiment were
University of California, Irvine The University of California, Irvine (UCI or UC Irvine) is a public land-grant research university in Irvine, California. One of the ten campuses of the University of California system, UCI offers 87 undergraduate degrees and 129 graduate and pr ...
and Institute for Medical and Biological Problems (IMBP). * Messenger
RNA Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...
Levels in Skeletal and Smooth Muscles: The objective of this experiment was to measure certain messenger RNA levels in various skeletal muscles and intestinal smooth muscle as an index of protein synthesis. Participated in the experiment the
University of Texas Medical Branch The University of Texas Medical Branch (UTMB) is a public academic health science center in Galveston, Texas. It is part of the University of Texas System. UTMB includes the oldest medical school in Texas, and has about 11,000 employees. In Febr ...
and Institute for Medical and Biological Problems (IMBP). * Measurement of
Heart The heart is a muscular organ in most animals. This organ pumps blood through the blood vessels of the circulatory system. The pumped blood carries oxygen and nutrients to the body, while carrying metabolic waste such as carbon dioxide t ...
Atrial
Natriuretic Peptide A natriuretic peptide is a peptide that induces natriuresis, which is the excretion of sodium by the kidneys. Known natriuretic peptides include the following: * atrial natriuretic peptide, also known as ANP * brain natriuretic peptide, also known ...
Concentrations: The objective of this experiment was to measure the cardiac hormone, which plays a role in water and salt balance, in cardiac tissue of rats exposed to spaceflight. Participated in the experiment the Institute for Medical and Biological Problems (IMBP) and
NASA Ames Research Center The Ames Research Center (ARC), also known as NASA Ames, is a major NASA research center at Moffett Federal Airfield in California's Silicon Valley. It was founded in 1939 as the second National Advisory Committee for Aeronautics (NACA) laborat ...
. * Morphological and Biochemical Examination of Heart Tissue: The objective of this experiment was to determine microgravity effects on rodent heart tissue ( ventricle). Participated in the experiment the
University of Chicago The University of Chicago (UChicago, Chicago, U of C, or UChi) is a private research university in Chicago, Illinois. Its main campus is located in Chicago's Hyde Park neighborhood. The University of Chicago is consistently ranked among the b ...
,
University of California, Irvine The University of California, Irvine (UCI or UC Irvine) is a public land-grant research university in Irvine, California. One of the ten campuses of the University of California system, UCI offers 87 undergraduate degrees and 129 graduate and pr ...
,
University of Texas Medical Branch The University of Texas Medical Branch (UTMB) is a public academic health science center in Galveston, Texas. It is part of the University of Texas System. UTMB includes the oldest medical school in Texas, and has about 11,000 employees. In Febr ...
, the
NASA Ames Research Center The Ames Research Center (ARC), also known as NASA Ames, is a major NASA research center at Moffett Federal Airfield in California's Silicon Valley. It was founded in 1939 as the second National Advisory Committee for Aeronautics (NACA) laborat ...
,
Baylor University Baylor University is a private Baptist Christian research university in Waco, Texas. Baylor was chartered in 1845 by the last Congress of the Republic of Texas. Baylor is the oldest continuously operating university in Texas and one of the fir ...
,
Texas Texas (, ; Spanish language, Spanish: ''Texas'', ''Tejas'') is a state in the South Central United States, South Central region of the United States. At 268,596 square miles (695,662 km2), and with more than 29.1 million residents in 2 ...
, and Institute for Medical and Biological Problems (IMBP). * Hepatic Function in Rats After Space Flight: The objective of this experiment was to determine the effect of
microgravity The term micro-g environment (also μg, often referred to by the term microgravity) is more or less synonymous with the terms ''weightlessness'' and ''zero-g'', but emphasising that g-forces are never exactly zero—just very small (on the I ...
on
liver The liver is a major Organ (anatomy), organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the Protein biosynthesis, synthesis of proteins and biochemicals necessary for ...
and plasma constituents, on the ability of the liver to metabolize food stuffs and foreign substances, and on liver
histology Histology, also known as microscopic anatomy or microanatomy, is the branch of biology which studies the microscopic anatomy of biological tissues. Histology is the microscopic counterpart to gross anatomy, which looks at larger structures vis ...
. The institutions participating in this experiment were
Emory University Emory University is a private research university in Atlanta, Georgia. Founded in 1836 as "Emory College" by the Methodist Episcopal Church and named in honor of Methodist bishop John Emory, Emory is the second-oldest private institution of ...
,
University of Louisville The University of Louisville (UofL) is a public research university in Louisville, Kentucky. It is part of the Kentucky state university system. When founded in 1798, it was the first city-owned public university in the United States and one of ...
and Institute for Medical and Biological Problems (IMBP). * Erythroid Colony Formation ''In Vitro'' and Erythropoietin Determinations: The objective of this experiment was to determine the effect of microgravity on the red blood cell production of rodents. Participated in the experiment the
University of Tennessee The University of Tennessee (officially The University of Tennessee, Knoxville; or UT Knoxville; UTK; or UT) is a public land-grant research university in Knoxville, Tennessee. Founded in 1794, two years before Tennessee became the 16th state, ...
, the Institute of Developmental Biology (U.S.S.R.), the Institute of Biophysics (
Czechoslovakia , rue, Чеськословеньско, , yi, טשעכאסלאוואקיי, , common_name = Czechoslovakia , life_span = 1918–19391945–1992 , p1 = Austria-Hungary , image_p1 ...
) and Institute for Medical and Biological Problems (IMBP). * Rat Testis Morphology and Physiology: The objective of this experiment was to determine the effects of microgravity on rodent testis physiology. The institutions participating in this experiment were Institute for Medical and Biological Problems (IMBP),
Colorado State University Colorado State University (Colorado State or CSU) is a public land-grant research university in Fort Collins, Colorado. It is the flagship university of the Colorado State University System. Colorado State University is classified among "R1: ...
,
Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...
,
Pennsylvania State University The Pennsylvania State University (Penn State or PSU) is a Public university, public Commonwealth System of Higher Education, state-related Land-grant university, land-grant research university with campuses and facilities throughout Pennsylvan ...
and
Johns Hopkins University Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hem ...
. * Structural Changes and Cell Turnover in the Rats Small Intestine: The objective of this experiment was to determine the structural changes and cell turnover in the small intestines of rats as a result of
spaceflight Spaceflight (or space flight) is an application of astronautics to fly spacecraft into or through outer space, either with or without humans on board. Most spaceflight is uncrewed and conducted mainly with spacecraft such as satellites in or ...
. Participated in the experiment the
Colorado State University Colorado State University (Colorado State or CSU) is a public land-grant research university in Fort Collins, Colorado. It is the flagship university of the Colorado State University System. Colorado State University is classified among "R1: ...
and Institute for Medical and Biological Problems (IMBP). * Effects of Muscle Atrophy on Motor End Plates: The objective of this experiment was to determine the effects of spaceflight on neurotransmitter receptors of the brain and spinal cord, and on the morphology and histochemistry of nerve-muscle junctions. Specifically, it studied the muscarinic and gaba (
benzodiazepine Benzodiazepines (BZD, BDZ, BZs), sometimes called "benzos", are a class of depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. They are prescribed to treat conditions such as anxiety disorders, ...
) receptors in the sensory-motor cortex and spinal cord. The institutions participating in this experiment were the
NASA Ames Research Center The Ames Research Center (ARC), also known as NASA Ames, is a major NASA research center at Moffett Federal Airfield in California's Silicon Valley. It was founded in 1939 as the second National Advisory Committee for Aeronautics (NACA) laborat ...
and Institute for Medical and Biological Problems (IMBP). * Pineal Physiology in Microgravity and Its Relation to Gonadal Function: The objective of this experiment was to determine the effect of microgravity on selected pineal gland neurotransmitters associated with rodent circadian rhythm control and correlate this with testis function. Participated in the experiment the Institute for Medical and Biological Problems (IMBP), the
San Jose State University San José State University (San Jose State or SJSU) is a public university in San Jose, California. Established in 1857, SJSU is the oldest public university on the West Coast and the founding campus of the California State University (CSU) sys ...
and the
Florida A&M University Florida Agricultural and Mechanical University (FAMU), commonly known as Florida A&M, is a public historically black land-grant university in Tallahassee, Florida. Founded in 1887, It is the third largest historically black university in the U ...
. * Pituitary Oxytocin and Vasopressin Content: The objective of this experiment was to determine the effect of microgravity on two pituitary hormones (
oxytocin Oxytocin (Oxt or OT) is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. It plays a role in social bonding, reproduction, childbirth, and the period after childbirth. Oxytocin ...
and
vasopressin Human vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the AVP gene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It then travel ...
) involved in water balance. Participated in the experiment the
NASA Ames Research Center The Ames Research Center (ARC), also known as NASA Ames, is a major NASA research center at Moffett Federal Airfield in California's Silicon Valley. It was founded in 1939 as the second National Advisory Committee for Aeronautics (NACA) laborat ...
and Institute for Medical and Biological Problems (IMBP). * Study of the Effect of
Microgravity The term micro-g environment (also μg, often referred to by the term microgravity) is more or less synonymous with the terms ''weightlessness'' and ''zero-g'', but emphasising that g-forces are never exactly zero—just very small (on the I ...
on
Enzymes Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecule ...
: The objective of this experiment was to study the effect of microgravity on 1) metabolic enzymes of type I, IIA, and IIB muscle fibers; and on 2) metabolic enzymes, neurotransmitter amino acids, and neurotransmitter associated enzymes in selected regions of the central nervous system. Participated in the experiment the
Washington University School of Medicine Washington University School of Medicine (WUSM) is the medical school of Washington University in St. Louis in St. Louis, Missouri. Founded in 1891, the School of Medicine has 1,260 students, 604 of which are pursuing a medical degree with or ...
and Institute for Medical and Biological Problems (IMBP). * Growth Hormone Regulation, Synthesis and Secretion in Microgravity: The objective of this experiment was to study growth hormone physiology in rodents during spaceflight. The institutions participating in this experiment were
Pennsylvania State University The Pennsylvania State University (Penn State or PSU) is a Public university, public Commonwealth System of Higher Education, state-related Land-grant university, land-grant research university with campuses and facilities throughout Pennsylvan ...
, Institute for Medical and Biological Problems (IMBP),
NASA Ames Research Center The Ames Research Center (ARC), also known as NASA Ames, is a major NASA research center at Moffett Federal Airfield in California's Silicon Valley. It was founded in 1939 as the second National Advisory Committee for Aeronautics (NACA) laborat ...
and Salk Institute of Biological Studies. * Effect of Space Flight on Level and Function of Immune Cells: The objective of this experiment was to determine the effects of spaceflight on various immunological parameters using rat spleen, bone marrow cells and
lymphocytes A lymphocyte is a type of white blood cell (leukocyte) in the immune system of most vertebrates. Lymphocytes include natural killer cells (which function in cell-mediated, cytotoxic innate immunity), T cells (for cell-mediated, cytotoxic adap ...
. Participated the
NASA Johnson Space Center The Lyndon B. Johnson Space Center (JSC) is NASA's center for human spaceflight (originally named the Manned Spacecraft Center), where human spaceflight training, research, and flight control are conducted. It was renamed in honor of the late U ...
,
Pennsylvania State University The Pennsylvania State University (Penn State or PSU) is a Public university, public Commonwealth System of Higher Education, state-related Land-grant university, land-grant research university with campuses and facilities throughout Pennsylvan ...
,
University of Louisville The University of Louisville (UofL) is a public research university in Louisville, Kentucky. It is part of the Kentucky state university system. When founded in 1798, it was the first city-owned public university in the United States and one of ...
and Institute for Medical and Biological Problems (IMBP). * Histologic Examination of Lung Tissue: The objective of this experiment was to determine the effect of microgravity on rat lung tissue. Participated the
University of California, San Diego The University of California, San Diego (UC San Diego or colloquially, UCSD) is a public university, public Land-grant university, land-grant research university in San Diego, California. Established in 1960 near the pre-existing Scripps Insti ...
and Institute for Medical and Biological Problems (IMBP). * Rodent Tissue Repair: The objective of this experiment was to determine the effects of microgravity on the repair of skin connective tissue and skeletal muscle. The institutions participating in this experiment were the
University of Kansas The University of Kansas (KU) is a public research university with its main campus in Lawrence, Kansas, United States, and several satellite campuses, research and educational centers, medical centers, and classes across the state of Kansas. Tw ...
, Institute for Medical and Biological Problems (IMBP),
West Virginia University West Virginia University (WVU) is a public land-grant research university with its main campus in Morgantown, West Virginia. Its other campuses are those of the West Virginia University Institute of Technology in Beckley, Potomac State College ...
and the
University of Wisconsin–Madison A university () is an educational institution, institution of higher education, higher (or Tertiary education, tertiary) education and research which awards academic degrees in several Discipline (academia), academic disciplines. Universities ty ...
. * Adaptation of Optokinetic Nystagmus to Microgravity: The objective of this experiment was to study primate eye movement responses in an upright position and at various angles of tilt, before and after spaceflight. The institutions participating in this experiment were
Brooklyn College Brooklyn College is a public university in Brooklyn, Brooklyn, New York. It is part of the City University of New York system and enrolls about 15,000 undergraduate and 2,800 graduate students on a 35-acre campus. Being New York City's first publ ...
in
New York City New York, often called New York City or NYC, is the List of United States cities by population, most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the L ...
,
Mount Sinai Medical Center Mount Sinai Hospital, formerly at times known as Mount Sinai Medical Center, is a 319-bed major urban hospital in Chicago, Illinois, with its main campus located adjacent to Douglass Park at 15th Street and California Avenue on the city's West Si ...
and Institute for Medical and Biological Problems (IMBP). * Studies of Vestibular Primary Afferents In Normal, Hyper- and Hypogravity: The objective of this experiment was to study the effect of microgravity on a primates vestibular system by measuring brain and eye movement responses to rotational stimuli preflight and postflight. Participated in the experiment
University of Texas Medical Branch The University of Texas Medical Branch (UTMB) is a public academic health science center in Galveston, Texas. It is part of the University of Texas System. UTMB includes the oldest medical school in Texas, and has about 11,000 employees. In Febr ...
and Institute for Medical and Biological Problems (IMBP). * Functional Neuromuscular Adaption to Spaceflight: The objective of this experiment was to study primate electromyographic activity (EMG) and to determine its importance to the maintenance of normal muscle properties. The biochemical and morphological effects of microgravity on muscles was also studied. Participated in the experiment
University of California, Los Angeles The University of California, Los Angeles (UCLA) is a public land-grant research university in Los Angeles, California. UCLA's academic roots were established in 1881 as a teachers college then known as the southern branch of the California St ...
(UCLA), Institute for Medical and Biological Problems (IMBP) and Moscow Medical Institute. * Biological Rhythm and Temperature Regulation: The objective of this experiment was to determine the functioning of a primate's circadian rhythm and thermoregulatory systems. Participated in the experiment the
University of California, Davis The University of California, Davis (UC Davis, UCD, or Davis) is a public land-grant research university near Davis, California. Named a Public Ivy, it is the northernmost of the ten campuses of the University of California system. The institut ...
and Institute for Medical and Biological Problems (IMBP). * Rhesus Monkey Metabolism during Spaceflight: The objective of this experiment was to determine the metabolic rates of primates during spaceflight. Participated in the experiment the
University of California, Davis The University of California, Davis (UC Davis, UCD, or Davis) is a public land-grant research university near Davis, California. Named a Public Ivy, it is the northernmost of the ten campuses of the University of California system. The institut ...
and Institute for Medical and Biological Problems (IMBP). * Radiation Dosimetry and Spectrometry - Passive Systems The objective of this experiment was to conduct a set of radiation measurements with passive detectors in order to study high and low energy neutrons, various flux and energy spectra, and the attenuation of
space radiation Health threats from cosmic rays are the dangers posed by cosmic rays to astronauts on interplanetary missions or any missions that venture through the Van-Allen Belts or outside the Earth's magnetosphere. They are one of the greatest barriers ...
as a function of shielding. The institutions participating in this experiment were the
NASA Marshall Space Flight Center The George C. Marshall Space Flight Center (MSFC), located in Redstone Arsenal, Alabama (Huntsville, Alabama, Huntsville postal address), is the Federal government of the United States, U.S. government's civilian rocketry and spacecraft propuls ...
,
University of San Francisco The University of San Francisco (USF) is a private Jesuit university in San Francisco, California. The university's main campus is located on a setting between the Golden Gate Bridge and Golden Gate Park. The main campus is nicknamed "The Hil ...
and Institute for Medical and Biological Problems (IMBP).


See also

* 1989 in spaceflight *
Animals in space Animals in space originally served to test the survivability of spaceflight, before human spaceflights were attempted. Later, other non-human animals were flown to investigate various biological processes and the effects microgravity and space ...


References


External links


NASA

U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044, NASA

U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044, NASA

"COSMOS 2044 MISSION", entire issue of which was dedicated to reports of joint U.S./U.S.S.R. research in space biomedicine on this specific 14-day spaceflight
Journal of Applied Physiology The ''Journal of Applied Physiology'' is a monthly peer-reviewed medical journal of physiology published by the American Physiological Society. The journal was established in 1948, and is currently edited by Sue Bodine. According to the ''Journal ...
73, 1992 {{Orbital launches in 1989 Bion satellites Kosmos satellites Spacecraft launched in 1989 1989 in spaceflight 1989 in the Soviet Union Czechoslovakia–Soviet Union relations Romania–Soviet Union relations Hungary–Soviet Union relations Poland–Soviet Union relations France–Soviet Union relations Soviet Union–United States relations East Germany–Soviet Union relations