Biphenylindanone A (BINA, LS-193,571) is a research agent which acts as a potent and selective positive allosteric modulator for the group II
metabotropic glutamate receptor subtype
mGluR2
Metabotropic glutamate receptor 2 (mGluR2) is a protein that, in humans, is encoded by the ''GRM2'' gene. mGluR2 is a G protein-coupled receptor (GPCR) that couples with the Gi alpha subunit. The receptor functions as an autoreceptor for glutam ...
.
In animal studies it showed
anxiolytic and
antipsychotic effects, and blocked the effects produced by the
hallucinogenic drug
DOB. BINA and other selective mGluR2 positive modulators have therefore been suggested as a novel class of drugs for the treatment of
schizophrenia which may have superior properties to traditional antipsychotic drugs.
BINA decreases cocaine
self-administration
Self-administration is, in its medical sense, the process of a subject administering a pharmacological substance to themself. A clinical example of this is the subcutaneous "self-injection" of insulin by a diabetic patient.
In animal experimentati ...
in rats, with no effect on food self-administration, and is in regard to this discrimination superior to the mGluR
2/3 agonist
LY-379,268.
References
Anxiolytics
Antipsychotics
MGlu2 receptor agonists
Cyclopentanes
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