Bicyclic phosphate is a class of
organophosphate compounds that are used as
flame retardant
The term flame retardants subsumes a diverse group of chemicals that are added to manufactured materials, such as plastics and textiles, and surface finishes and coatings. Flame retardants are activated by the presence of an ignition source and ...
s, stabilizers and
antioxidants. They are also used in spectroscopic studies.
Some bicyclic phosphates, such as
TBPS,
TBPO and
IPTBO
IPTBO (isopropylbicyclophosphate, also IPPO) is a bicyclic phosphate convulsant. It is an extremely potent GABA receptor antagonist that can cause violent convulsions in mice.
IPTBO is found among a group of highly toxic bicyclic phosphates. Ge ...
, are highly toxic. They have toxicity comparable to
nerve agent
Nerve agents, sometimes also called nerve gases, are a class of organic chemicals that disrupt the mechanisms by which nerves transfer messages to organs. The disruption is caused by the blocking of acetylcholinesterase (AChE), an enzyme that ...
s. However, they are not
acetylcholinesterase inhibitor
Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and ...
s.
They act as GABA receptor antagonists and have potent
convulsant A convulsant is a drug which induces convulsions and/or epileptic seizures, the opposite of an anticonvulsant. These drugs generally act as stimulants at low doses, but are not used for this purpose due to the risk of convulsions and consequent e ...
effects.
See also
*
Convulsant A convulsant is a drug which induces convulsions and/or epileptic seizures, the opposite of an anticonvulsant. These drugs generally act as stimulants at low doses, but are not used for this purpose due to the risk of convulsions and consequent e ...
*
TBPS
*
TBPO
*
IPTBO
IPTBO (isopropylbicyclophosphate, also IPPO) is a bicyclic phosphate convulsant. It is an extremely potent GABA receptor antagonist that can cause violent convulsions in mice.
IPTBO is found among a group of highly toxic bicyclic phosphates. Ge ...
References
Convulsants
Neurotoxins
GABAA receptor negative allosteric modulators
Organophosphates
Phosphate esters
{{Neurotoxin-stub